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Evaluation of cerebral autoregulation performance in patients with arterial hypertension on drug treatment.
Machado, Michel Ferreira; Muela, Henrique Cotchi Simbo; Costa-Hong, Valeria Aparecida; Yassuda, Monica Sanches; Moraes, Natalia Cristina; Memória, Claudia Maia; Bor-Seng-Shu, Edson; Massaro, Ayrton Roberto; Nitrini, Ricardo; Bortolotto, Luiz Aparecido; Nogueira, Ricardo de Carvalho.
Afiliación
  • Machado MF; Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
  • Muela HCS; Instituto do Coração (Incor), University of São Paulo Medical School - Hypertension Unit, São Paulo, Brazil.
  • Costa-Hong VA; Instituto do Coração (Incor), University of São Paulo Medical School - Hypertension Unit, São Paulo, Brazil.
  • Yassuda MS; Gerontology, School of Arts, Sciences and Humanities, University of São Paulo Medical School, São Paulo, Brazil.
  • Moraes NC; Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
  • Memória CM; Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
  • Bor-Seng-Shu E; Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
  • Massaro AR; Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
  • Nitrini R; Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
  • Bortolotto LA; Instituto do Coração (Incor), University of São Paulo Medical School - Hypertension Unit, São Paulo, Brazil.
  • Nogueira RC; Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
J Clin Hypertens (Greenwich) ; 22(11): 2114-2120, 2020 11.
Article en En | MEDLINE | ID: mdl-32966689
Cerebral autoregulation (AR) keeps cerebral blood flow constant despite fluctuations in systemic arterial pressure. The final common AR pathway is made up of vasomotor adjustments of cerebrovascular resistance mediated by arterioles. Structural and functional changes in the arteriolar wall arise with age and systemic arterial hypertension. This study evaluated whether AR is impaired in hypertensive patients and whether this impairment differs with disease control. Three groups of patients were prospectively compared: hypertensive patients under treatment with systolic blood pressure (SBP) <140 and diastolic blood pressure (DBP) <90 mm Hg (n = 54), hypertensive patients under treatment with SBP > 140 or DBP > 90 mm Hg (n = 31), and normotensive volunteers (n = 30). Simultaneous measurements of cerebral blood flow velocity (CBFV) and BP were obtained by digital plethysmography and transcranial Doppler, and the AR index (ARI) was defined according to the step response to spontaneous fluctuations in BP. Compared to the uncontrolled hypertension, the normotensive individuals were younger (age 43.42 ± 11.14, P < .05) and had a lower resistance-area product (1.17 ± 0.24, P < .05), although age and greater arteriolar stiffness did not affect the CBFV mean of hypertensive patients, whether controlled or uncontrolled (62.85 × 58.49 × 58.30 cm/s, P = .29), most likely because their ARIs were not compromised (5.54 × 5.91 × 5.88, P = .6). Hypertensive patients under treatment, regardless of their BP control, have intact AR capacity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertensión Límite: Adult / Humans / Middle aged Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertensión Límite: Adult / Humans / Middle aged Idioma: En Revista: J Clin Hypertens (Greenwich) Asunto de la revista: ANGIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos