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Alphaherpesvirus Vaccines.
Aschner, Clare Burn; Herold, Betsy C.
Afiliación
  • Aschner CB; Department of Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Herold BC; Department of Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Curr Issues Mol Biol ; 41: 469-508, 2021.
Article en En | MEDLINE | ID: mdl-32963118
Prophylactic and therapeutic vaccines for the alphaherpesviruses including varicella zoster virus (VZV) and herpes simplex virus types 1 and 2 have been the focus of enormous preclinical and clinical research. A live viral vaccine for prevention of chickenpox and a subunit therapeutic vaccine to prevent zoster are highly successful. In contrast, progress towards the development of effective prophylactic or therapeutic vaccines against HSV-1 and HSV-2 has met with limited success. This review provides an overview of the successes and failures, the different types of immune responses elicited by various vaccine modalities, and the need to reconsider the preclinical models and immune correlates of protection against HSV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas Virales / Alphaherpesvirinae / Infecciones por Herpesviridae Límite: Animals / Humans Idioma: En Revista: Curr Issues Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas Virales / Alphaherpesvirinae / Infecciones por Herpesviridae Límite: Animals / Humans Idioma: En Revista: Curr Issues Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza