Your browser doesn't support javascript.
loading
Adiponectin is Increased in Pediatric Patients With Autoimmune Hepatitis Independent of Body Weight.
Cortez, Ana Paula Bidutte; Mattar, Regina Helena Guedes da Motta; de Azevedo, Ramiro Anthero; Fisberg, Mauro; Lederman, Henrique Manoel; de Morais, Mauro Batista.
Afiliación
  • Cortez APB; Division of Pediatric Gastroenterology, Federal University of São Paulo (UNIFESP).
  • Mattar RHGDM; Division of Pediatric Gastroenterology, Federal University of São Paulo (UNIFESP).
  • de Azevedo RA; Division of Pediatric Gastroenterology, Federal University of São Paulo (UNIFESP).
  • Fisberg M; Department of Pediatrics, Federal University of São Paulo (UNIFESP).
  • Lederman HM; Nutrition and Feeding Difficulties Center- Pensi Institute - Jose Luiz Setubal Foundation.
  • de Morais MB; Senior Prof. of Radiology, Department of Diagnostic Imaging, Federal University of São Paulo (UNIFESP). São Paulo, SP, Brazil.
J Pediatr Gastroenterol Nutr ; 71(4): e118-e123, 2020 10.
Article en En | MEDLINE | ID: mdl-32960544
OBJECTIVE: A high prevalence of obesity is reported in children and adolescents with autoimmune hepatitis (AIH). Adipokines participate in inflammatory processes. The objective of this study was to examine the relationship between excess weight and systemic inflammation, adipokines, and ghrelin in adolescents with AIH. METHOD: This case-controlled study included 27 adolescents with AIH (13 with excess weight and 14 with normal weight) and a control group. Excess weight was defined by a body mass index/age Z score >+1 standard deviation. Adipokines (adiponectin, leptin, tumor necrosis factor alpha, interleukin 6 [IL-6], and IL-10) and ghrelin were measured with Luminex technology. RESULTS: Adiponectin (µg/mL) was higher (P < 0.001) in AIH adolescents with and without excess weight (median: 35.0 and 42.1, respectively) than in normal-weight (17.5) and excess-weight (17.0) controls. Leptin was higher (P < 0.001) in excess-weight AIH patients (18.0 ng/mL) and controls (19.8 ng/mL) than in normal-weight AIH (7.7 ng/mL) and control (7.0 ng/mL) adolescents. IL-6 levels were higher in excess-weight (3.8 pg/mL) and normal-weight (3.8 pg/mL) AIH patients than in excess-weight (1.1 pg/mL) and normal-weight (0.5 pg/mL) controls. IL-10 levels were higher (5.2 pg/mL) in normal-weight AIH patients than in excess-weight (1.8 pg/mL) and normal-weight (2.1 pg/mL) controls. Ferritin levels were lower in patients with AIH than in controls. CONCLUSIONS: Independent of body weight, AIH patients had higher levels of adipokines, especially adiponectin and IL-6. Leptin levels were associated with body weight and were not influenced by AIH. IL-10 levels were associated with lean tissue in AIH.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatitis Autoinmune / Adiponectina Tipo de estudio: Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatitis Autoinmune / Adiponectina Tipo de estudio: Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos