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Two polyphenol-rich Brazilian fruit extracts protect from diet-induced obesity and hepatic steatosis in mice.
Ballard, Cíntia Reis; Dos Santos, Elisvânia Freitas; Dubois, Marie-Julie; Pilon, Geneviève; Cazarin, Cinthia Baú Betim; Maróstica Junior, Mário Roberto; Marette, Andre.
Afiliación
  • Ballard CR; Department of Food and Nutrition, School of Food Engineering, University of Campinas, Campinas, 80 Monteiro Lobato, 13083-862, São Paulo, Brazil. cintia.reis.ballard@gmail.com cbetim@unicamp.br mario@fea.unicamp.br.
  • Dos Santos EF; School of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, S/N Costa e Silva, 79070-900, Mato Grosso do Sul, Brazil. elisvania@gmail.com.
  • Dubois MJ; Quebec Heart and Lung Institute, Laval Hospital, Laval University, Quebec City, 2725 Sainte Foy, G1V 4G5, Quebec, Canada. Marie-Julie.Dubois@criucpq.ulaval.ca Genevieve.Pilon@criucpq.ulaval.ca Andre.Marette@criucpq.ulaval.ca.
  • Pilon G; Quebec Heart and Lung Institute, Laval Hospital, Laval University, Quebec City, 2725 Sainte Foy, G1V 4G5, Quebec, Canada. Marie-Julie.Dubois@criucpq.ulaval.ca Genevieve.Pilon@criucpq.ulaval.ca Andre.Marette@criucpq.ulaval.ca.
  • Cazarin CBB; Department of Food and Nutrition, School of Food Engineering, University of Campinas, Campinas, 80 Monteiro Lobato, 13083-862, São Paulo, Brazil. cintia.reis.ballard@gmail.com cbetim@unicamp.br mario@fea.unicamp.br.
  • Maróstica Junior MR; Department of Food and Nutrition, School of Food Engineering, University of Campinas, Campinas, 80 Monteiro Lobato, 13083-862, São Paulo, Brazil. cintia.reis.ballard@gmail.com cbetim@unicamp.br mario@fea.unicamp.br.
  • Marette A; Quebec Heart and Lung Institute, Laval Hospital, Laval University, Quebec City, 2725 Sainte Foy, G1V 4G5, Quebec, Canada. Marie-Julie.Dubois@criucpq.ulaval.ca Genevieve.Pilon@criucpq.ulaval.ca Andre.Marette@criucpq.ulaval.ca.
Food Funct ; 11(10): 8800-8810, 2020 Oct 21.
Article en En | MEDLINE | ID: mdl-32959866
Consumption of polyphenol-rich food is associated with better metabolic health. Tucum-do-Pantanal (Bactris setosa Mart) and taruma-do-cerrado (Vitex cymosa Bertero ex Spreng) are underexploited native Brazilian fruits with an important source of phytochemicals. In this study, we assessed the effects of 100 mg kg-1 tucum (TPE) and taruma (TCE) extracts on diet-induced obesity (DIO) C57BL/6J mice. After 8 weeks of daily treatment, TPE and TCE were found to significantly prevented the diet-induced body weight gain and fully protected against hepatic steatosis associated with a tendency to stimulate hepatic AMPK phosphorylation. TPE reduced visceral obesity and improved glucose metabolism as revealed by an improvement of the insulin tolerance test, a reduction in the insulin fasting level, and a decreased glucose-induced hyperinsulinemia during an oral glucose tolerance test. TPE and TCE showed promising effects on the treatment of obesity and NAFLD, furthermore, TPE on insulin resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Vitex / Arecaceae / Polifenoles / Enfermedad del Hígado Graso no Alcohólico / Frutas / Obesidad Tipo de estudio: Etiology_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Food Funct Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Vitex / Arecaceae / Polifenoles / Enfermedad del Hígado Graso no Alcohólico / Frutas / Obesidad Tipo de estudio: Etiology_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Food Funct Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido