Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment.

Subramani, Elavarasan; Radoul, Marina; Najac, Chloe; Batsios, Georgios; Molloy, Abigail R; Hong, Donghyun; Gillespie, Anne Marie; Santos, Romelyn Delos; Viswanath, Pavithra; Costello, Joseph F; Pieper, Russell O; Ronen, Sabrina M

Subramani, Elavarasan; Radoul, Marina; Najac, Chloe; Batsios, Georgios; Molloy, Abigail R; Hong, Donghyun; Gillespie, Anne Marie; Santos, Romelyn Delos; Viswanath, Pavithra; Costello, Joseph F; Pieper, Russell O; Ronen, Sabrina M.

Afiliación

Subramani E; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Radoul M; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Najac C; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Batsios G; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Molloy AR; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Hong D; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Gillespie AM; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Santos RD; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Viswanath P; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Costello JF; Department of Neurological Surgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Pieper RO; Department of Neurological Surgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Ronen SM; Brain Tumor Research Center, University of California San Francisco, San Francisco, California.

Cancer Res ; 80(22): 5098-5108, 2020 11 15.

Article en En | MEDLINE | ID: mdl-32958546

Asunto(s)

Antineoplásicos Alquilantes/uso terapéutico; Biomarcadores de Tumor/metabolismo; Neoplasias Encefálicas/metabolismo; Glioma/metabolismo; Ácido Glutámico/metabolismo; Isocitrato Deshidrogenasa/genética; Temozolomida/uso terapéutico; Animales; Neoplasias Encefálicas/tratamiento farmacológico; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/patología; Isótopos de Carbono; Femenino; Glioma/tratamiento farmacológico; Glioma/genética; Glioma/patología; Glucosa/metabolismo; Glutamina/metabolismo; Humanos; Isocitrato Deshidrogenasa/metabolismo; Ácidos Cetoglutáricos/metabolismo; Espectroscopía de Resonancia Magnética/métodos; Ratones; Ratones Desnudos; Mutación; Ingeniería de Proteínas; Ácido Pirúvico/metabolismo; Distribución Aleatoria; Resultado del Tratamiento

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Biomarcadores de Tumor / Ácido Glutámico / Antineoplásicos Alquilantes / Temozolomida / Glioma / Isocitrato Deshidrogenasa Tipo de estudio: Clinical_trials / Prognostic_studies / Screening_studies Límite: Animals / Female / Humans Idioma: En Revista: Cancer Res Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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