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Male fetal sex is associated with low maternal plasma anti-inflammatory cytokine profile in the first trimester of healthy pregnancies.
Ramiro-Cortijo, David; de la Calle, María; Böger, Rainer; Hannemann, Juliane; Lüneburg, Nicole; López-Giménez, María Rosario; Rodríguez-Rodríguez, Pilar; Martín-Cabrejas, María Ángeles; Benítez, Vanesa; de Pablo, Ángel Luis López; González, María Del Carmen; Arribas, Silvia M.
Afiliación
  • Ramiro-Cortijo D; Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  • de la Calle M; Obstetrics and Gynecology Service, La Paz University Hospital, Madrid, Spain.
  • Böger R; Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hannemann J; Department of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Lüneburg N; Hospital Pharmacy, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
  • López-Giménez MR; Department of Preventive Medicine, Public Health & Microbiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  • Rodríguez-Rodríguez P; Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  • Martín-Cabrejas MÁ; Institute of Food Science Research (CIAL) & Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain.
  • Benítez V; Institute of Food Science Research (CIAL) & Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain.
  • de Pablo ÁLL; Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  • González MDC; Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  • Arribas SM; Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address: silvia.arribas@uam.es.
Cytokine ; 136: 155290, 2020 12.
Article en En | MEDLINE | ID: mdl-32956948
Male fetal sex associates with higher rates of materno-fetal complications. Inflammation and inadequate vasoactive responses are mechanisms implicated in obstetric complications, and alterations in maternal plasma cytokine profile and nitric oxide (NO) metabolites are potential predictive biomarkers. We aimed to assess if these parameters are influenced by fetal sex. A prospective, observational study was carried out in 85 healthy pregnant women with singleton pregnancies in the first trimester of gestation. A blood sample was extracted at the tenth week of gestation. In plasma, we assessed: 1) cytokines (micro-array): pro-inflammatory (IL1α, IL1 ß, IL6, TNFα), anti-inflammatory (IL4, IL10, IL13), and chemoattractant (IL8, MCP1, IFNγ), and 2) NO metabolites (liquid chromatography-tandem mass spectrometry and Griess reaction): L-arginine, ADMA, SDMA, nitrates (NOx). Women with a male fetus (n = 50) exhibited, compared with those with a female (n = 35): higher IL1ß (OR = 1.09 with 95% CI: 0.97-1.28), and lower IL13 (OR = 0.93 with 95% CI: 0.87-0.99), and higher plasma NOx (OR = 1.14 with 95% CI: 1.03-1.31). Our data suggest that fetal sex influences maternal plasma cytokine profile and NO in early pregnancy. Women with a male fetus may have a worse capacity to counteract an inflammatory response. They may have better vasodilator capacity, but in the presence of an oxidative environment, a higher nitrosative damage may occur. These data reinforce the need to include sex as variable in predictive models.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Primer Trimestre del Embarazo / Embarazo / Citocinas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Primer Trimestre del Embarazo / Embarazo / Citocinas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido