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[The influence of apolipoprotein A1 on the prognosis of multiple myeloma].
Shen, J; Yang, R H; Zhang, Y C; Liao, A J; Liu, Z G; Yang, W.
Afiliación
  • Shen J; Department of Hematology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
  • Yang RH; Department of Blood Transfusion, China Medical University First Hospital, Shenyang 110001, China.
  • Zhang YC; Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang 110004, China.
  • Liao AJ; Department of Hematology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
  • Liu ZG; Department of Hematology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
  • Yang W; Department of Hematology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Zhonghua Xue Ye Xue Za Zhi ; 41(8): 675-679, 2020 Aug 14.
Article en Zh | MEDLINE | ID: mdl-32942823
Objective: In this study, we aimed to determine the change and clinical significance of serum level Apo A1 in MM patients. Methods: In total, 412 multiple myeloma patients were examined. SPSS 22.0 was used for data analysis. Correlation analysis was performed using linear correlation or Spearman rank correlation coefficients. Measurement data were analyzed with the t-test, Mann-Whitney U-test, or oneway analysis of variance (ANOVA) . Used the ROC curve to calculate the cutoff value and compared the OS and PFS between high Apo A1 subgroup and low Apo A1 subgroup with Kaplan-Meier survival analysis. Results: Our study showed that value of Apo A1 in the patient group was lower than that in the control group (0.89 g/L vs 1.24 g/L, P<0.05) . We found that Apo A1 dynamically changed with different MM stages. As it was increased when the disease was in remission, and decreased after disease in progression. According the result of multivariate analysis Apo A1 reduction become the independent risk factors of MM. On the basis of Kaplan-Meier survival analysis between high Apo A1 subgroup and low Apo A1 subgroup, we found higher Apo A1 patienta had longer OS rate and PFS. Conclusions: Apo A1 is a useful biomarker of tumor burden and a prognostic factor of multiple myeloma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mieloma Múltiple Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: Zh Revista: Zhonghua Xue Ye Xue Za Zhi Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mieloma Múltiple Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: Zh Revista: Zhonghua Xue Ye Xue Za Zhi Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: China