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Regional Alterations in Cortical Sulcal Depth in Living Fetuses with Down Syndrome.
Yun, Hyuk Jin; Perez, Juan David Ruiz; Sosa, Patricia; Valdés, J Alejandro; Madan, Neel; Kitano, Rie; Akiyama, Shizuko; Skotko, Brian G; Feldman, Henry A; Bianchi, Diana W; Grant, P Ellen; Tarui, Tomo; Im, Kiho.
Afiliación
  • Yun HJ; Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Perez JDR; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Sosa P; Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Valdés JA; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Madan N; Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Kitano R; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Akiyama S; Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Skotko BG; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Feldman HA; Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA.
  • Bianchi DW; Mother Infant Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
  • Grant PE; Mother Infant Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
  • Tarui T; Down Syndrome Program, Genetics, Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Im K; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cereb Cortex ; 31(2): 757-767, 2021 01 05.
Article en En | MEDLINE | ID: mdl-32940649
Down syndrome (DS) is the most common genetic cause of developmental disabilities. Advanced analysis of brain magnetic resonance imaging (MRI) has been used to find brain abnormalities and their relationship to neurocognitive impairments in children and adolescents with DS. Because genetic factors affect brain development in early fetal life, there is a growing interest in analyzing brains from living fetuses with DS. In this study, we investigated regional sulcal folding depth as well as global cortical gyrification from fetal brain MRIs. Nine fetuses with DS (29.1 ± 4.24 gestational weeks [mean ± standard deviation]) were compared with 17 typically developing [TD] fetuses (28.4 ± 3.44). Fetuses with DS showed lower whole-brain average sulcal depths and gyrification index than TD fetuses. Significant decreases in sulcal depth were found in bilateral Sylvian fissures and right central and parieto-occipital sulci. On the other hand, significantly increased sulcal depth was shown in the left superior temporal sulcus, which is related to atypical hemispheric asymmetry of cortical folding. Moreover, these group differences increased as gestation progressed. This study demonstrates that regional sulcal depth is a sensitive marker for detecting alterations of cortical development in DS during fetal life, which may be associated with later neurocognitive impairment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Síndrome de Down / Feto Límite: Adolescent / Adult / Humans Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Síndrome de Down / Feto Límite: Adolescent / Adult / Humans Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos