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Efficient degradation of ivermectin by newly isolated Aeromonas taiwanensis ZJB-18,044.
Wang, Yuanshan; Gong, Meihua; Wang, Xianlin; Peng, Xiaolun; Wang, Yuwei; Guan, Jiahui; Cheng, Dongyuan; Weng, Chunyue; Zheng, Yuguo.
Afiliación
  • Wang Y; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.
  • Gong M; Engineering Research Center of Bioconversion and Biopurification, Ministry of Education, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.
  • Wang X; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.
  • Peng X; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.
  • Wang Y; Engineering Research Center of Bioconversion and Biopurification, Ministry of Education, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.
  • Guan J; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.
  • Cheng D; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.
  • Weng C; Engineering Research Center of Bioconversion and Biopurification, Ministry of Education, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.
  • Zheng Y; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, Zhejiang, People's Republic of China.
Biodegradation ; 31(4-6): 275-288, 2020 12.
Article en En | MEDLINE | ID: mdl-32936376
Ivermectin (IVM) is a widely used antiparasitic agent and acaricide. Despite its high efficiency against nematodes and arthropods, IVM may pose a threat to the environment due to its ecotoxcity. In this study, degradation of IVM by a newly isolated bacterium Aeromonas taiwanensis ZJB-18,044 was investigated. Strain ZJB-18,044 can completely degrade 50 mg/L IVM in 5 d with a biodegradation ability of 0.42 mg/L/h. Meanwhile, it exhibited high tolerance (50 mg/L) to doramectin, emamectin, rifampicin, and spiramycin. It can also efficiently degrade doramectin, emamectin, and spiramycin. The IVM degradation of strain ZJB-18,044 can be inhibited by erythromycin, azithromycin, spiramycin or rifampicin. However, supplement of carbonyl cyanide m-chlorophenylhydrazone, an uncoupler of oxidative phosphorylation, can partially recover the IVM degradation. Moreover, strain ZJB-18,044 cells can pump out excess IVM to maintain a low intracellular IVM concentration. Therefore, the IVM tolerance of strain ZJB-18,044 may be due to the regulation of the intracellular IVM concentration by the activated macrolide efflux pump(s). With the high IVM degradation efficiency, A. taiwanensis ZJB-18,044 may serve as a bioremediation agent for IVM and other macrolides in the environment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ivermectina / Aeromonas Idioma: En Revista: Biodegradation Asunto de la revista: BIOQUIMICA / SAUDE AMBIENTAL Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ivermectina / Aeromonas Idioma: En Revista: Biodegradation Asunto de la revista: BIOQUIMICA / SAUDE AMBIENTAL Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos