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Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy.
Cai, Ying; Zheng, Chao; Xiong, Fengqin; Ran, Wei; Zhai, Yihui; Zhu, Helen H; Wang, Hao; Li, Yaping; Zhang, Pengcheng.
Afiliación
  • Cai Y; State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Zheng C; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Xiong F; State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Ran W; China State Institute of Pharmaceutical Industry, Shanghai, 200040, China.
  • Zhai Y; State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Zhu HH; China State Institute of Pharmaceutical Industry, Shanghai, 200040, China.
  • Wang H; State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Li Y; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhang P; State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Adv Healthc Mater ; 10(1): e2001239, 2021 01.
Article en En | MEDLINE | ID: mdl-32935937
Supramolecular peptide hydrogel (SPH) is a class of biomaterials self-assembled from peptide-based gelators through non-covalent interactions. Among many of its biomedical applications, the potential of SPH in cancer therapy has been vastly explored in the past decade, taking advantage of its good biocompatibility, multifunctionality, and injectability. SPHs can exert localized cancer therapy and induce systemic anticancer immunity to prevent tumor recurrence, depending on the design of SPH. This review first gives a brief introduction to SPH and then outlines the major types of peptide-based gelators that have been developed so far. The methodologies to tune the physicochemical properties and biological activities are summarized. The recent advances of SPH in cancer therapy as carriers, prodrugs, or drugs are highlighted. Finally, the clinical translation potential and main challenges in this field are also discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Neoplasias Idioma: En Revista: Adv Healthc Mater Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Neoplasias Idioma: En Revista: Adv Healthc Mater Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania