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Mitochondria membrane transformations in colon and prostate cancer and their biological implications.
Zichri, Shani Ben; Kolusheva, Sofiya; Shames, Alexander I; Schneiderman, Elina Abaev; Poggio, Juan L; Stein, David E; Doubijensky, Elena; Levy, Dan; Orynbayeva, Zulfiya; Jelinek, Raz.
Afiliación
  • Zichri SB; Department of Chemistry, Ben-Gurion University, Beer-Sheva 84105, Israel.
  • Kolusheva S; Ilze Katz Center for Nanotechnology, Ben-Gurion University, Beer-Sheva 84105, Israel.
  • Shames AI; Department of Physics, Ben-Gurion University, Beer-Sheva 84105, Israel.
  • Schneiderman EA; Department of Microbiology, Immunology and Genetics, Faculty for Health Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.
  • Poggio JL; Department of Surgery, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
  • Stein DE; Department of Surgery, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
  • Doubijensky E; Ilze Katz Center for Nanotechnology, Ben-Gurion University, Beer-Sheva 84105, Israel.
  • Levy D; Department of Microbiology, Immunology and Genetics, Faculty for Health Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.
  • Orynbayeva Z; Department of Surgery, Drexel University College of Medicine, Philadelphia, PA 19102, USA. Electronic address: zo25@drexel.edu.
  • Jelinek R; Department of Chemistry, Ben-Gurion University, Beer-Sheva 84105, Israel; Ilze Katz Center for Nanotechnology, Ben-Gurion University, Beer-Sheva 84105, Israel. Electronic address: razj@bgu.ac.il.
Biochim Biophys Acta Biomembr ; 1863(1): 183471, 2021 01 01.
Article en En | MEDLINE | ID: mdl-32931774
Mitochondria have emerged as important determinants in cancer progression and malignancy. However, the role of mitochondrial membranes in cancer onset and progression has not been thoroughly investigated. This study compares the structural and functional properties of mitochondrial membranes in prostate and colon cancer cells in comparison to normal mitochondria, and possible therapeutic implications of these membrane changes. Specifically, isolation of cell mitochondria and preparation of inverted sub-mitochondrial particles (SMPs) illuminated significant cancer-induced modulations of membrane lipid compositions, fluidity, and activity of cytochrome c oxidase, one of the key mitochondrial enzymes. The experimental data further show that cancer-associated membrane transformations may account for mitochondria targeting by betulinic acid and resveratrol, known anti-cancer molecules. Overall, this study probes the relationship between cancer and mitochondrial membrane transformations, underlying a potential therapeutic significance for mitochondrial membrane targeting in cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Neoplasias del Colon / Proteínas Mitocondriales / Membranas Mitocondriales / Lípidos de la Membrana / Mitocondrias / Proteínas de Neoplasias Límite: Humans / Male Idioma: En Revista: Biochim Biophys Acta Biomembr Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Neoplasias del Colon / Proteínas Mitocondriales / Membranas Mitocondriales / Lípidos de la Membrana / Mitocondrias / Proteínas de Neoplasias Límite: Humans / Male Idioma: En Revista: Biochim Biophys Acta Biomembr Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Países Bajos