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Treatment of Partial Thickness Burns: A Prospective, Randomized Controlled Trial Comparing Four Routinely Used Burns Dressings in an Ambulatory Care Setting.
Aggarwala, Shivani; Harish, Varun; Roberts, Sarah; Brady, Megan; Lajevardi, Sepehr; Doherty, James; D'Souza, Mario; Haertsch, Peter A; Maitz, Peter K M; Issler-Fisher, Andrea C.
Afiliación
  • Aggarwala S; Burns Unit, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
  • Harish V; University of Sydney, Camperdown, New South Wales, Australia.
  • Roberts S; Burns Unit, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
  • Brady M; University of Sydney, Camperdown, New South Wales, Australia.
  • Lajevardi S; Burns Unit, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
  • Doherty J; Burns Unit, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
  • D'Souza M; Burns Unit, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
  • Haertsch PA; University of Sydney, Camperdown, New South Wales, Australia.
  • Maitz PKM; Burns Unit, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
  • Issler-Fisher AC; Burns Unit, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
J Burn Care Res ; 42(5): 934-943, 2021 09 30.
Article en En | MEDLINE | ID: mdl-32930784
This prospective, randomized controlled trial study compared the effects of four dressings for adult partial thickness burns, focusing on re-epithelialization time and cost effectiveness. Adults with partial thickness burns meeting inclusion criteria were randomized to either Biobrane™, Acticoat™, Mepilex® Ag, or Aquacel® Ag. Primary endpoint for analysis was >95% re-epithelialization. Incremental cost-effectiveness ratios were calculated based on dressing costs. Dominance probabilities between treatment arms were calculated from bootstrap resampling trial data. One hunderd thirty-one partial thickness burn wounds in 119 patients were randomized. Adjusting for sex, age, smoking status, burn mechanism, TBSA, and first aid adequacy, Mepilex® Ag had a reduced time to re-epithelialization compared to Biobrane™ (IRR: 1.26; 95% CI: 1.07-1.48, P < .01). Economic analysis showed that there was a 99%, 71%, and 53% probability that Mepilex® Ag dominated (cheaper and more effective) Biobrane™, Acticoat™, and Aquacel® Ag, respectively. Mepilex® Ag achieved faster re-epithelialization and better cost effectiveness. Patient satisfaction and comfort seems better with Biobrane™ although not reflected within the end outcome of the healed wound. It is the patients' (after extensive education) and clinicians' choice, level of experience, and availability of products in praxis that will guide the decision as to which the product is used individually on which patient.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sitoesteroles / Quemaduras / Carboximetilcelulosa de Sodio / Compuestos de Plata / Materiales Biocompatibles Revestidos / Antiinfecciosos Locales Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Burn Care Res Asunto de la revista: TRAUMATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sitoesteroles / Quemaduras / Carboximetilcelulosa de Sodio / Compuestos de Plata / Materiales Biocompatibles Revestidos / Antiinfecciosos Locales Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Burn Care Res Asunto de la revista: TRAUMATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido