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Infection Dynamics of Swine Influenza Virus in a Danish Pig Herd Reveals Recurrent Infections with Different Variants of the H1N2 Swine Influenza A Virus Subtype.
Bhatta, Tarka Raj; Ryt-Hansen, Pia; Nielsen, Jens Peter; Larsen, Lars Erik; Larsen, Inge; Chamings, Anthony; Goecke, Nicole B; Alexandersen, Soren.
Afiliación
  • Bhatta TR; Geelong Centre for Emerging Infectious Diseases, Geelong, VIC 3220, Australia.
  • Ryt-Hansen P; School of Medicine, Deakin University, Geelong, VIC 3220, Australia.
  • Nielsen JP; Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
  • Larsen LE; Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
  • Larsen I; Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
  • Chamings A; Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
  • Goecke NB; Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.
  • Alexandersen S; Geelong Centre for Emerging Infectious Diseases, Geelong, VIC 3220, Australia.
Viruses ; 12(9)2020 09 10.
Article en En | MEDLINE | ID: mdl-32927910
Influenza A virus (IAV) in swine, so-called swine influenza A virus (swIAV), causes respiratory illness in pigs around the globe. In Danish pig herds, a H1N2 subtype named H1N2dk is one of the main circulating swIAV. In this cohort study, the infection dynamic of swIAV was evaluated in a Danish pig herd by sampling and PCR testing of pigs from two weeks of age until slaughter at 22 weeks of age. In addition, next generation sequencing (NGS) was used to identify and characterize the complete genome of swIAV circulating in the herd, and to examine the antigenic variability in the antigenic sites of the virus hemagglutinin (HA) and neuraminidase (NA) proteins. Overall, 76.6% of the pigs became PCR positive for swIAV during the study, with the highest prevalence at four weeks of age. Detailed analysis of the virus sequences obtained showed that the majority of mutations occurred at antigenic sites in the HA and NA proteins of the virus. At least two different H1N2 variants were found to be circulating in the herd; one H1N2 variant was circulating at the sow and nursery sites, while another H1N2 variant was circulating at the finisher site. Furthermore, it was demonstrated that individual pigs had recurrent swIAV infections with the two different H1N2 variants, but re-infection with the same H1N2 variant was also observed. Better understandings of the epidemiology, genetic and antigenic diversity of swIAV may help to design better health interventions for the prevention and control of swIAV infections in the herds.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Orthomyxoviridae / Subtipo H1N2 del Virus de la Influenza A / Reinfección Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Animals País/Región como asunto: Europa Idioma: En Revista: Viruses Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Orthomyxoviridae / Subtipo H1N2 del Virus de la Influenza A / Reinfección Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Animals País/Región como asunto: Europa Idioma: En Revista: Viruses Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza