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HoBi-like pestivirus infection leads to bovine death and severe respiratory disease in China.
Chen, Meng; Liu, Mengda; Liu, Sidang; Shang, Yingli.
Afiliación
  • Chen M; College of Veterinary Medicine, Shandong Agricultural University, Taian, China.
  • Liu M; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian, China.
  • Liu S; Laboratory of Zoonoses, China Animal Health and Epidemiology Center, Qingdao, China.
  • Shang Y; College of Veterinary Medicine, Shandong Agricultural University, Taian, China.
Transbound Emerg Dis ; 68(3): 1069-1074, 2021 May.
Article en En | MEDLINE | ID: mdl-32926568
HoBi-like pestivirus is an emerging atypical pestivirus in cattle and small ruminants, causing clinical signs similar to those observed in bovine viral diarrhoea virus infections. Natural infection of HoBi-like pestivirus has been reported in cattle herds and small ruminants in multiple countries in South America, Europe and Asia. However, HoBi-like pestiviruses were only identified from contaminated bovine serum and small ruminants in China. So far, no clinical cases induced by HoBi-like pestivirus infection were reported in Chinese cattle herds. Here, for the first time, we reported natural infection of HoBi-like pestivirus in a cattle herd in China. Sick cattle with severe respiratory and diarrhoea and high fatality rate were found in a beef cattle herd in Shandong province in November 2017. RT-PCR, viral isolation, sequencing and phylogenetic analysis showed that the primary causative agent was HoBi-like pestivirus. The isolated HoBi-like pestivirus strain, SDJN-China-2019, shared 94.1%-97.5% homology with the LV168-20_16RN strain from Brazil in nucleotide of 5'UTR, Npro and E2 while it shared only 88.5%-92.1% homology with Asian HoBi-like virus strain Th/04-Khonkaen. Multiple unique mutations of amino acid were observed in Npro and E2 proteins of SDJN-China-2019, which were different from that of other reference strains. In summary, this study provides the first evidence of HoBi-like pestivirus infection in Chinese cattle herds, raising potential threat to the cattle industry in China.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Enfermedades de los Bovinos / Infecciones por Pestivirus / Pestivirus Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Transbound Emerg Dis Asunto de la revista: MEDICINA VETERINARIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Enfermedades de los Bovinos / Infecciones por Pestivirus / Pestivirus Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Transbound Emerg Dis Asunto de la revista: MEDICINA VETERINARIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania