Palladium-Catalyzed Monoarylation of Arylhydrazines with Aryl Tosylates.

Huang, Yange; Choy, Pui Ying; Wang, Junya; Tse, Man-Kin; Sun, Raymond Wai-Yin; Chan, Albert Sun-Chi; Kwong, Fuk Yee

Huang, Yange; Choy, Pui Ying; Wang, Junya; Tse, Man-Kin; Sun, Raymond Wai-Yin; Chan, Albert Sun-Chi; Kwong, Fuk Yee.

Afiliación

Huang Y; Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic Molecules, Shenzhen Research Institute, The Chinese University of Hong Kong, No. 10, Second Yuexing Road, Shenzhen 518507, China.
Choy PY; State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The Chinese University of Hong Kong, New Territories, Shatin, Hong Kong, China.
Wang J; Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic Molecules, Shenzhen Research Institute, The Chinese University of Hong Kong, No. 10, Second Yuexing Road, Shenzhen 518507, China.
Tse MK; State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The Chinese University of Hong Kong, New Territories, Shatin, Hong Kong, China.
Sun RW; Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic Molecules, Shenzhen Research Institute, The Chinese University of Hong Kong, No. 10, Second Yuexing Road, Shenzhen 518507, China.
Chan AS; Guangzhou Lee & Man Technology Co. Ltd, Rm 401, Blk A, 8 Huanshi Avenue South, Nansha, Guangzhou, China.
Kwong FY; Guangzhou Lee & Man Technology Co. Ltd, Rm 401, Blk A, 8 Huanshi Avenue South, Nansha, Guangzhou, China.

J Org Chem ; 85(22): 14664-14673, 2020 11 20.

Article en En | MEDLINE | ID: mdl-32924493

RESUMEN

A palladium-catalyzed C-N bond coupling reaction between arylhydrazines and aryl tosylates for facile synthesis of unsymmetrical N,N-diarylhydrazines has been developed. Employing the catalyst system of Pd(TFA)2 associated with newly developed phosphine ligand L1, the monoarylation of arylhydrazine proceeds smoothly to afford desired products in good-to-excellent yields (up to 95%) with good functional group compatibility. This method provides an alternative synthetic pathway for accessing structurally diversified N,N-diarylhydrazines from simple and easily accessible coupling components.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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