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Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits.
Katsuda, Shin-Ichiro; Fujikura, Yuko; Horikoshi, Yuko; Hazama, Akihiro; Shimizu, Tsuyoshi; Shirai, Kohji.
Afiliación
  • Katsuda SI; Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine.
  • Fujikura Y; Yuri Kumiai General Hospital.
  • Horikoshi Y; Department of Clinical Laboratory Sciences,School of Health Sciences, Fukushima Medical University.
  • Hazama A; Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine.
  • Shimizu T; Shimizu Institute of Space Physiology, Suwa Maternity Clinic.
  • Shirai K; Seijinkai Mihama Hospital.
J Atheroscler Thromb ; 28(6): 611-621, 2021 Jun 01.
Article en En | MEDLINE | ID: mdl-32921698
AIM: The mechanism underlying the stiffness of the aorta and iliofemoral artery that is required to maintain blood pressure (BP) is unclear. A new stiffness index of the aorta (aBeta) and iliac-femoral arteries (ifBeta) was defined by applying the cardio-ankle vascular index (CAVI). We compared changes in stiffness of the two arteries in response to reduced BP, due to the non-selective α adrenergic blocker phentolamine and the ß1 adrenergic blocker atenolol, in rabbits. METHODS: Pressure waves at the origin (oA) and distal ends of the aorta (dA) and the distal end of the left femoral artery (fA) were recorded simultaneously using three pressure sensors in 25 anesthetized rabbits. Phentolamine (50 µg/kg/min) and atenolol (10 mg/kg/min) were infused for 2 min. The pulse wave velocity (PWV) in each artery was determined; aBeta, ifBeta, and whole Beta (aifBeta) were calculated by the following formula; Beta=2ρ/PP×ln(SBP/DBP)×PWV2 (ρ: blood density; SBP, SBP, and PP: systolic, diastolic, and pulse pressures, respectively). RESULTS: SBP and DBP at oA, dA, and fA decreased by the administration of phentolamine and atenolol, with and without decreased total peripheral vascular resistance. After phentramine infusion, cardiac output (CO), aBeta, and aifBeta increased, while ifBeta decreased. After infusion of atenolol, CO decreased, while aBeta, ifBeta, and aifBeta remained unchanged. CONCLUSION: The contradictory reactions of aBeta and ifBeta to phentolamine suggest that the stiffness of the aorta and ilio-femoral artery is regulated separately during decreased BP induced by phentolamine, but not by atenolol.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta / Fentolamina / Atenolol / Velocidad del Flujo Sanguíneo / Arteria Femoral / Rigidez Vascular Límite: Animals Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta / Fentolamina / Atenolol / Velocidad del Flujo Sanguíneo / Arteria Femoral / Rigidez Vascular Límite: Animals Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Japón