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Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride via modulating the redox imbalance, Bax/Bcl-2 and NF-kB signaling pathways in male rats.
Arab-Nozari, Milad; Ahangar, Nematollah; Mohammadi, Ebrahim; Lorigooini, Zahra; Shokrzadeh, Mohammad; Amiri, Fereshteh Talebpour; Shaki, Fatemeh.
Afiliación
  • Arab-Nozari M; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
  • Ahangar N; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran.
  • Mohammadi E; Department of Pharmacology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Lorigooini Z; Environmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Shokrzadeh M; Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  • Amiri FT; Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
  • Shaki F; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Mol Biol Rep ; 47(9): 6961-6972, 2020 Sep.
Article en En | MEDLINE | ID: mdl-32920758
Aim of this study was to investigate the efficacy of Ginkgo Biloba (G.B) hydro-ethanolic extract against hepatotoxicity induced by combined exposure to cadmium (Cd) and fluoride (F) in Wistar rats. Animals were exposed to F (30 mg/L) + Cd (40 mg/L), F + Cd plus G.B (50,100 and 200 mg/kg), G.B (200 mg/kg), F + Cd plus Vit C(1000 mg/L) in drinking water for 42 days. Significant raise in liver enzymes and histopathological changes were observed in F + Cd treated rats. F + Cd exposure enhanced protein and glutathione oxidation, lipid peroxidation and decreased superoxide dismutase activity. F and Cd combination also caused mitochondrial dysfunction, swelling and mitochondrial membrane potential collapse in liver isolated mitochondria. Up-regulation of inflammatory genes (TNF-α, IL-1ß and NF-kB) and pro-apoptotic Bax as well as down-regulation of anti-apoptotic Bcl-2 were detected after co-exposure to F and Cd. Interestingly, G.B alleviated F + Cd induced liver oxidative stress, mitochondrial damage and prevented inflammation and apoptosis. Furthermore, decrease in serum liver enzymes and improvement of histopathologic lesions were observed in G.B treated rats. This study explored the potential beneficial role of G.B on F + Cd combined hepatotoxic effects via considering its possible antioxidant, anti-inflammatory, mitochondrial protection and anti-apoptotic effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Extractos Vegetales / Transducción de Señal / FN-kappa B / Proteínas Proto-Oncogénicas c-bcl-2 / Ginkgo biloba / Proteína X Asociada a bcl-2 / Enfermedad Hepática Inducida por Sustancias y Drogas / Fluoruros Límite: Animals Idioma: En Revista: Mol Biol Rep Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Extractos Vegetales / Transducción de Señal / FN-kappa B / Proteínas Proto-Oncogénicas c-bcl-2 / Ginkgo biloba / Proteína X Asociada a bcl-2 / Enfermedad Hepática Inducida por Sustancias y Drogas / Fluoruros Límite: Animals Idioma: En Revista: Mol Biol Rep Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos