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Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.
Zhang, Chenxi; Shao, Zhenxuan; Chen, Zhentai; Lin, Chen; Hu, Sunli; Lou, Zhiling; Li, Jiafeng; Zheng, Xuanqi; Lin, Nan; Gao, Weiyang.
Afiliación
  • Zhang C; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P. R. China.
  • Shao Z; Zhejiang Provincial Key Laboratory of Orthopaedics Wenzhou 325000, Zhejiang, P. R. China.
  • Chen Z; The Second Clinical Medical College of Wenzhou Medical University Wenzhou 325027, P. R. China.
  • Lin C; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P. R. China.
  • Hu S; Zhejiang Provincial Key Laboratory of Orthopaedics Wenzhou 325000, Zhejiang, P. R. China.
  • Lou Z; The Second Clinical Medical College of Wenzhou Medical University Wenzhou 325027, P. R. China.
  • Li J; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P. R. China.
  • Zheng X; Zhejiang Provincial Key Laboratory of Orthopaedics Wenzhou 325000, Zhejiang, P. R. China.
  • Lin N; The Second Clinical Medical College of Wenzhou Medical University Wenzhou 325027, P. R. China.
  • Gao W; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P. R. China.
Am J Transl Res ; 12(8): 4781-4794, 2020.
Article en En | MEDLINE | ID: mdl-32913550
The use of perforator flaps is a common surgical technique in wound repair. However, the area surrounding the multiterritory perforating flap often becomes necrotic due to ischemia. Hydroxysafflor yellow A (HSYA), a traditional Chinese medicine extracted from edible safflower, can be used medicinally to promote angiogenesis, inhibit apoptosis, and alleviate oxidative stress and other biological activities. Here, we investigated the effect of HSYA on perforator flap survival and its potential mechanism. Our results demonstrate that HSYA significantly improves the survival area of perforator flaps, increases blood supply, reduces tissue edema, and increases mean vascular density. HSYA treatment promotes angiogenesis and inhibits oxidative stress, apoptosis, and autophagy in perforator flaps, suggesting many potential mechanisms for flap survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Transl Res Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Transl Res Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos