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SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells.
Oliemuller, Erik; Newman, Richard; Tsang, Siu Man; Foo, Shane; Muirhead, Gareth; Noor, Farzana; Haider, Syed; Aurrekoetxea-Rodríguez, Iskander; Vivanco, Maria dM; Howard, Beatrice A.
Afiliación
  • Oliemuller E; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Newman R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Tsang SM; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Foo S; Translational Immunotherapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
  • Muirhead G; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Noor F; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Haider S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Aurrekoetxea-Rodríguez I; CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
  • Vivanco MD; CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
  • Howard BA; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
Elife ; 92020 09 10.
Article en En | MEDLINE | ID: mdl-32909943
SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High SOX11 levels in breast tumours are significantly associated with distant metastasis and poor outcome in breast cancer patients. Here, we show that SOX11 confers distinct features to ER-negative DCIS.com breast cancer cells, leading to populations enriched with highly plastic hybrid epithelial/mesenchymal cells, which display invasive features and alterations in metastatic tropism when xenografted into mice. We found that SOX11+DCIS tumour cells metastasize to brain and bone at greater frequency and to lungs at lower frequency compared to cells with lower SOX11 levels. High levels of SOX11 leads to the expression of markers associated with mesenchymal state and embryonic cellular phenotypes. Our results suggest that SOX11 may be a potential biomarker for breast tumours with elevated risk of developing metastases and may require more aggressive therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Factores de Transcripción SOXC / Transición Epitelial-Mesenquimal / Invasividad Neoplásica Límite: Animals / Female / Humans Idioma: En Revista: Elife Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Factores de Transcripción SOXC / Transición Epitelial-Mesenquimal / Invasividad Neoplásica Límite: Animals / Female / Humans Idioma: En Revista: Elife Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido