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Diagnosis and prevalence of diabetic polyneuropathy: a cross-sectional study of Danish patients with type 2 diabetes.
Gylfadottir, S S; Itani, M; Krøigård, T; Kristensen, A G; Christensen, D H; Nicolaisen, S K; Karlsson, P; Callaghan, B C; Bennett, D L; Andersen, H; Tankisi, H; Nielsen, J S; Andersen, N T; Jensen, T S; Thomsen, R W; Sindrup, S H; Finnerup, N B.
Afiliación
  • Gylfadottir SS; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Itani M; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
  • Krøigård T; Department of Neurology, Odense University Hospital, Odense, Denmark.
  • Kristensen AG; Department of Neurology, Odense University Hospital, Odense, Denmark.
  • Christensen DH; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Nicolaisen SK; Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
  • Karlsson P; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
  • Callaghan BC; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
  • Bennett DL; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Andersen H; Core Center for Molecular Morphology, Section for Stereology and Microscopy, Aarhus University, Aarhus, Denmark.
  • Tankisi H; Department of Neurology, University of Michigan, Ann Arbor,, MI, USA.
  • Nielsen JS; Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.
  • Andersen NT; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
  • Jensen TS; Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
  • Thomsen RW; Danish Centre for Strategic Research in Type 2 Diabetes, Steno Diabetes Center, Odense, Denmark.
  • Sindrup SH; Biostatistics, Department of Public Health, Aarhus University, Aarhus, Denmark.
  • Finnerup NB; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Eur J Neurol ; 27(12): 2575-2585, 2020 12.
Article en En | MEDLINE | ID: mdl-32909392
BACKGROUND AND PURPOSE: Diabetic polyneuropathy (DPN) is a common complication of diabetes. Using the Toronto criteria for diabetic polyneuropathy and the grading system for neuropathic pain, the performance of neuropathy scales and questionnaires were assessed by comparing them to a clinical gold standard diagnosis of DPN and painful DPN in a cohort of patients with recently diagnosed type 2 diabetes. METHODS: A questionnaire on neuropathy and pain was sent to a cohort of 5514 Danish type 2 diabetes patients. A sample of 389 patients underwent a detailed clinical examination and completed neuropathy questionnaires and scales. RESULTS: Of the 389 patients with a median diabetes duration of 5.9 years, 126 had definite DPN (including 53 with painful DPN), 88 had probable DPN and 53 had possible DPN. There were 49 patients with other causes of polyneuropathy, neuropathy symptoms or pain, 10 with subclinical DPN and 63 without DPN. The sensitivity of the Michigan Neuropathy Screening Instrument questionnaire to detect DPN was 25.7% and the specificity 84.6%. The sensitivity of the Toronto Clinical Neuropathy Scoring System, including questionnaire and clinical examination, was 62.9% and the specificity was 74.6%. CONCLUSIONS: Diabetic polyneuropathy affects approximately one in five Danish patients with recently diagnosed type 2 diabetes but neuropathic pain is not as common as previously reported. Neuropathy scales with clinical examination perform better compared with questionnaires alone, but better scales are needed for future epidemiological studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido