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Implications of flavonoids as potential modulators of cancer neovascularity.
Liskova, Alena; Koklesova, Lenka; Samec, Marek; Varghese, Elizabeth; Abotaleb, Mariam; Samuel, Samson Mathews; Smejkal, Karel; Biringer, Kamil; Petras, Martin; Blahutova, Dana; Bugos, Ondrej; Pec, Martin; Adamkov, Marian; Büsselberg, Dietrich; Ciccocioppo, Rachele; Adamek, Mariusz; Rodrigo, Luis; Caprnda, Martin; Kruzliak, Peter; Kubatka, Peter.
Afiliación
  • Liskova A; Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
  • Koklesova L; Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
  • Samec M; Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
  • Varghese E; Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha, 24144, Qatar.
  • Abotaleb M; Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha, 24144, Qatar.
  • Samuel SM; Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha, 24144, Qatar.
  • Smejkal K; Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
  • Biringer K; Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
  • Petras M; Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
  • Blahutova D; Department of Biology and Ecology, Faculty of Education, Catholic University in Ruzomberok, Ruzomberok, Slovakia.
  • Bugos O; Lambda Life JSC., Bratislava, Slovakia.
  • Pec M; Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01, Martin, Slovakia.
  • Adamkov M; Department of Histology and Embryology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.
  • Büsselberg D; Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha, 24144, Qatar. dib2015@qatar-med.cornell.edu.
  • Ciccocioppo R; Gastroenterology Unit, Department of Medicine, Azienda Ospedaliera Universitaria Integrata Policlinico GB Rossi, University of Verona, Verona, Italy.
  • Adamek M; Department of Thoracic Surgery, Faculty of Medicine and Dentistry, Medical University of Silesia, Katowice, Poland.
  • Rodrigo L; Faculty of Medicine, University of Oviedo, Central University Hospital of Asturias (HUCA), Oviedo, Spain.
  • Caprnda M; 1st Department of Internal Medicine, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia.
  • Kruzliak P; 2nd Department of Surgery, Faculty of Medicine, Masaryk University, Pekarska 53, 656 91, Brno, Czech Republic. kruzliakpeter@gmail.com.
  • Kubatka P; St. Anne's University Hospital, Brno, Czech Republic. kruzliakpeter@gmail.com.
J Cancer Res Clin Oncol ; 146(12): 3079-3096, 2020 Dec.
Article en En | MEDLINE | ID: mdl-32902794
PURPOSE: The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of anti-angiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients. METHODS: This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. RESULTS AND CONCLUSION: Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Inhibidores de la Angiogénesis / Neoplasias / Neovascularización Patológica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2020 Tipo del documento: Article País de afiliación: Eslovaquia Pais de publicación: Alemania
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Inhibidores de la Angiogénesis / Neoplasias / Neovascularización Patológica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2020 Tipo del documento: Article País de afiliación: Eslovaquia Pais de publicación: Alemania