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Low­dose trametinib and Bcl­xL antagonist have a specific antitumor effect in KRAS­mutated colorectal cancer cells.
Koyama, Makoto; Kitazawa, Masato; Nakamura, Satoshi; Matsumura, Tomio; Miyazaki, Satoru; Miyagawa, Yusuke; Muranaka, Futoshi; Tokumaru, Shigeo; Okumura, Masahiro; Yamamoto, Yuta; Ehara, Takehito; Hondo, Nao; Takahata, Shugo; Takeoka, Michiko; Miyagawa, Shin-Ichi; Soejima, Yuji.
Afiliación
  • Koyama M; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Kitazawa M; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Nakamura S; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Matsumura T; Anaeropharma Science, Inc., Matsumoto, Nagano 390­8621, Japan.
  • Miyazaki S; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Miyagawa Y; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Muranaka F; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Tokumaru S; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Okumura M; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Yamamoto Y; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Ehara T; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Hondo N; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Takahata S; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Takeoka M; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Miyagawa SI; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
  • Soejima Y; Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Nagano 390­8621, Japan.
Int J Oncol ; 57(5): 1179-1191, 2020 11.
Article en En | MEDLINE | ID: mdl-32901840
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridonas / Pirimidinonas / Neoplasias Colorrectales / Proteínas Proto-Oncogénicas p21(ras) / Proteína bcl-X / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Int J Oncol Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridonas / Pirimidinonas / Neoplasias Colorrectales / Proteínas Proto-Oncogénicas p21(ras) / Proteína bcl-X / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Int J Oncol Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia