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Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice.
Kang, Yi; Nasr, Marjan; Guo, Yiru; Uchida, Shizuka; Weirick, Tyler; Li, Hong; Kim, Jae; Moore, Joseph B; Muthusamy, Senthilkumar; Bolli, Roberto; Wysoczynski, Marcin.
Afiliación
  • Kang Y; Diabetes and Obesity Center, University of Louisville School of Medicine, 580 South Preston St. - Rm 204B, Louisville, KY, 40202, USA.
  • Nasr M; Diabetes and Obesity Center, University of Louisville School of Medicine, 580 South Preston St. - Rm 204B, Louisville, KY, 40202, USA.
  • Guo Y; Institute of Molecular Cardiology, University of Louisville School of Medicine, Louisville, KY, USA.
  • Uchida S; Cardiovascular Innovation Institute, Univerity of Louisville School of Medicine, Louisville, KY, USA.
  • Weirick T; Cardiovascular Innovation Institute, Univerity of Louisville School of Medicine, Louisville, KY, USA.
  • Li H; Diabetes and Obesity Center, University of Louisville School of Medicine, 580 South Preston St. - Rm 204B, Louisville, KY, 40202, USA.
  • Kim J; Diabetes and Obesity Center, University of Louisville School of Medicine, 580 South Preston St. - Rm 204B, Louisville, KY, 40202, USA.
  • Moore JB; Diabetes and Obesity Center, University of Louisville School of Medicine, 580 South Preston St. - Rm 204B, Louisville, KY, 40202, USA.
  • Muthusamy S; Diabetes and Obesity Center, University of Louisville School of Medicine, 580 South Preston St. - Rm 204B, Louisville, KY, 40202, USA.
  • Bolli R; Institute of Molecular Cardiology, University of Louisville School of Medicine, Louisville, KY, USA.
  • Wysoczynski M; Diabetes and Obesity Center, University of Louisville School of Medicine, 580 South Preston St. - Rm 204B, Louisville, KY, 40202, USA. m0wyso01@louisville.edu.
Sci Rep ; 10(1): 14754, 2020 09 08.
Article en En | MEDLINE | ID: mdl-32901075
Although cardiac mesenchymal cell (CMC) therapy mitigates post-infarct cardiac dysfunction, the underlying mechanisms remain unidentified. It is acknowledged that donor cells are neither appreciably retained nor meaningfully contribute to tissue regeneration-suggesting a paracrine-mediated mechanism of action. As the immune system is inextricably linked to wound healing/remodeling in the ischemically injured heart, the reparative actions of CMCs may be attributed to their immunoregulatory properties. The current study evaluated the consequences of CMC administration on post myocardial infarction (MI) immune responses in vivo and paracrine-mediated immune cell function in vitro. CMC administration preferentially elicited the recruitment of cell types associated with innate immunity (e.g., monocytes/macrophages and neutrophils). CMC paracrine signaling assays revealed enhancement in innate immune cell chemoattraction, survival, and phagocytosis, and diminished pro-inflammatory immune cell activation; data that identifies and catalogues fundamental immunomodulatory properties of CMCs, which have broad implications regarding the mechanism of action of CMCs in cardiac repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miocitos Cardíacos / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas / Inmunidad Innata / Macrófagos / Infarto del Miocardio / Neutrófilos Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miocitos Cardíacos / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas / Inmunidad Innata / Macrófagos / Infarto del Miocardio / Neutrófilos Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido