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Obesity, COVID-19 and innate immunometabolism.
Gleeson, Laura E; Roche, Helen M; Sheedy, Frederick J.
Afiliación
  • Gleeson LE; School of Medicine, Trinity College, Dublin, Republic of Ireland.
  • Roche HM; Department of Respiratory Medicine, St James's Hospital, Dublin, Republic of Ireland.
  • Sheedy FJ; School of Public Health, Physiotherapy and Sports Science, University College Dublin, Republic of Ireland.
Br J Nutr ; 125(6): 628-632, 2021 03 28.
Article en En | MEDLINE | ID: mdl-32892755
As COVID-19 continues to spread worldwide, severe disease and mortality have been observed in obese patients. We discuss how obesity and obesity-associated factors such as 'meta-flammation', dietary fat intake and paradoxical suppression of the innate immune response within the pulmonary compartment may be crucial determinants in the host response to a novel viral pathogen. Modulation of immune cell bioenergetics and metabolic potential plays a central role in the innate immune response to infection, and as we strive to combat this new global health threat, immunometabolism of the innate immune system warrants attention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 / Sistema Inmunológico / Obesidad Límite: Humans Idioma: En Revista: Br J Nutr Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 / Sistema Inmunológico / Obesidad Límite: Humans Idioma: En Revista: Br J Nutr Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido