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Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B.
Parra, Marcela; Weitner, Megan; Yang, Amy; Akue, Adovi; Liu, Xia; Schmidt, Thomas; Allman, Windy R; Akkoyunlu, Mustafa; Derrick, Steven C.
Afiliación
  • Parra M; United States Food and Drug Administration, Center for Biologics and Research, Division of Bacterial, Parasitic and Allergenic Diseases, Silver Spring, Maryland, United States of America.
  • Weitner M; United States Food and Drug Administration, Center for Biologics and Research, Division of Bacterial, Parasitic and Allergenic Diseases, Silver Spring, Maryland, United States of America.
  • Yang A; United States Food and Drug Administration, Center for Biologics and Research, Division of Bacterial, Parasitic and Allergenic Diseases, Silver Spring, Maryland, United States of America.
  • Akue A; United States Food and Drug Administration, Center for Biologics and Research, Division of Bacterial, Parasitic and Allergenic Diseases, Silver Spring, Maryland, United States of America.
  • Liu X; United States Food and Drug Administration, Center for Biologics and Research, Division of Bacterial, Parasitic and Allergenic Diseases, Silver Spring, Maryland, United States of America.
  • Schmidt T; United States Food and Drug Administration, Center for Biologics and Research, Division of Bacterial, Parasitic and Allergenic Diseases, Silver Spring, Maryland, United States of America.
  • Allman WR; United States Food and Drug Administration, Center for Biologics and Research, Division of Bacterial, Parasitic and Allergenic Diseases, Silver Spring, Maryland, United States of America.
  • Akkoyunlu M; United States Food and Drug Administration, Center for Biologics and Research, Division of Bacterial, Parasitic and Allergenic Diseases, Silver Spring, Maryland, United States of America.
  • Derrick SC; United States Food and Drug Administration, Center for Biologics and Research, Division of Bacterial, Parasitic and Allergenic Diseases, Silver Spring, Maryland, United States of America.
PLoS One ; 15(9): e0238493, 2020.
Article en En | MEDLINE | ID: mdl-32886698
To better understand anti-malaria protective immune responses, we examined the cellular mechanisms that govern protective immunity in a murine Plasmodium yoelii 17X NL (PyNL) re-infection model. Initially, we confirmed that immune B cells generated during a primary PyNL infection were largely responsible for protection from a second PyNL infection. Using the previously identified memory B cell markers CD80, PD-L2, and CD73, we found an increase in the frequency of CD80-PD-L2-CD73+ B cells up to 55 days after a primary PyNL infection and at 4-6 days following a second PyNL infection. Moreover, injection of enriched immune CD19+CD73+ B cells into nonimmune mice were significantly more protective against a PyNL infection than CD73- B cells. Interestingly, a substantial fraction of these CD73+ B cells also expressed IgM and granzyme B, a biomolecule that has been increasingly associated with protective responses against malaria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: 5'-Nucleotidasa / Granzimas / Malaria Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: 5'-Nucleotidasa / Granzimas / Malaria Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos