ANOVA, analysis of variance; AUC, area under curve; Apoptosis; CC, calibration curve; CH-S, catechin-hydrate-suspension; CS, chitosan; CS-CTH-PLGA-NPs; CS-CTH-PLGA-NPs, chitosan-coated catechin hydrate-loaded-PLGA-nanoparticles; CTH, Catechin hydrate; Catechin hydrate; Cmax, maximum plasma concentration; DCM, dichloromethane; DSC, differential scanning calorimetry; EE, entrapment efficiency; ESI, Electrospray ionization; HQC, high quality control; IS, internal standard; Kel, elimination rate constant; LC, loading capacity; LLOQ, liquid­liquid extraction: LLE: lower limit of quantification; LLOQQC, lower limit of quantification for quality control; LOD, lower limit of detection; LOQ, lower limit of quantitation; Lung cancer; Lungs comparative pulmokinetics; MQC, low quality control: LQC: middle quality control; NPs, nanoparticles; PBS, phosphate buffered solution; PDI, polydispersity index; PVA, polyvinyl alcohol; SEM, scanning electron microscope; TEM, transmission electron microscope; Tmax, time to Cmax; UHPLC-MS/MS; UHPLC-MS/MS, ultra high performance liquid chromatography mass spectroscopy and mass spectroscopy; t½, half-life