Physiologically Based Pharmacokinetic Modeling Involving Nonlinear Plasma and Tissue Binding: Application to Prednisolone and Prednisone in Rats.

Li, Xiaonan; DuBois, Debra C; Almon, Richard R; Jusko, William J

Li, Xiaonan; DuBois, Debra C; Almon, Richard R; Jusko, William J.

Afiliación

Li X; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., R.R.A., W.J.J.) and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York.
DuBois DC; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., R.R.A., W.J.J.) and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York.
Almon RR; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., R.R.A., W.J.J.) and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York.
Jusko WJ; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., R.R.A., W.J.J.) and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York wjjusko@buffalo.edu.

J Pharmacol Exp Ther ; 375(2): 385-396, 2020 11.

Article en En | MEDLINE | ID: mdl-32883831

Asunto(s)

Modelos Biológicos; Dinámicas no Lineales; Prednisolona/sangre; Prednisolona/farmacocinética; Prednisona/sangre; Prednisona/farmacocinética; Animales; Masculino; Ratas; Ratas Wistar; Distribución Tisular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prednisolona / Prednisona / Dinámicas no Lineales / Modelos Biológicos Límite: Animals Idioma: En Revista: J Pharmacol Exp Ther Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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