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TPO antibody positivity and adverse pregnancy outcomes.
Dhillon-Smith, R K; Coomarasamy, A.
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  • Dhillon-Smith RK; Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; Tommy's Centre for Miscarriage Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; Centre for Women's and Newborn Health, Birmingham Women's and Children's Foundation Trust, Edgbaston, Birmingham, B15 2TG, UK. Electronic address: r.k.smith@bham.ac.uk.
  • Coomarasamy A; Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; Tommy's Centre for Miscarriage Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; Centre for Women's and Newborn Health, Birmingham Women's and Children's Foundation Trust, Edgbaston, Birmingham, B15 2TG, UK.
Best Pract Res Clin Endocrinol Metab ; 34(4): 101433, 2020 07.
Article en En | MEDLINE | ID: mdl-32883611
Thyroid autoimmunity (TAI) is prevalent amongst women of reproductive age. TAI describes the presence of circulating anti-thyroid autoantibodies that are targeted against the thyroid, with or without thyroid dysfunction. Thyroid peroxidase antibodies (TPOAb) are the most common anti-thyroid autoantibodies. Around 10% of biochemically euthyroid individuals also have an elevated TPOAb titre. Many studies have linked the presence of TPOAb to adverse maternal and fetal outcomes in pregnancy, in particular miscarriage and pre-term birth, even in the absence of thyroid dysfunction. The causal pathway is poorly understood and few trials have looked to find treatments to reduce adverse outcomes. This review discusses in detail the associated adverse outcomes of TPOAb in pregnancy and the results of trials exploring methods to reduce such outcomes. Recommendations for counselling and monitoring of women with TPOAb and suggested areas for future work are also outlined.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Autoanticuerpos / Enfermedades de la Tiroides / Resultado del Embarazo Tipo de estudio: Etiology_studies / Guideline Límite: Female / Humans / Pregnancy Idioma: En Revista: Best Pract Res Clin Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Autoanticuerpos / Enfermedades de la Tiroides / Resultado del Embarazo Tipo de estudio: Etiology_studies / Guideline Límite: Female / Humans / Pregnancy Idioma: En Revista: Best Pract Res Clin Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos