Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase.
Cell Adh Migr
; 14(1): 153-164, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-32881638
FNDC4 is an anti-inflammatory factor that alters the activation state of macrophages; it is used to treat colitis in mice. However, its role in muscle formation and mechanism of function remains unknown. We found that FNDC4 promotes the bovine MDSCs migration and differentiation. Furthermore, we reported that it interacts with integrin ß1 (ITGß1). FAK, mediated by ITGß1, regulates cell migration. Our results found FNDC4 to influence the expression of p-FAK, p-paxillin, and vinculin. Then, overexpressed or added FNDC4 protein could not influence migration and differentiation any more when the activated form of FAK was reduced. Therefore, we concluded that FNDC4 promotes the differentiation and migration of bovine MDSCs via the FAK, mediated by the ITGß1 receptor.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas
/
Diferenciación Celular
/
Movimiento Celular
/
Células Satélite del Músculo Esquelético
/
Proteína-Tirosina Quinasas de Adhesión Focal
/
Dominio de Fibronectina del Tipo III
Límite:
Animals
Idioma:
En
Revista:
Cell Adh Migr
Año:
2020
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos