Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure.

Machhada, Asif; Hosford, Patrick S; Dyson, Alex; Ackland, Gareth L; Mastitskaya, Svetlana; Gourine, Alexander V

Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure.

Machhada, Asif; Hosford, Patrick S; Dyson, Alex; Ackland, Gareth L; Mastitskaya, Svetlana; Gourine, Alexander V.

Afiliación

Machhada A; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
Dyson A; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Ackland GL; Clinical Physiology, Division of Medicine, University College London, London, United Kingdom.
Mastitskaya S; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Gourine AV; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.

JACC Basic Transl Sci ; 5(8): 799-810, 2020 Aug.

Article en En | MEDLINE | ID: mdl-32875170

Palabras clave

ABP, arterial blood pressure; DVMN, dorsal motor nucleus of the vagus nerve; GRK2, G-protein−coupled receptor kinase 2; LAD, left anterior descending coronary artery; LV dP/dtMAX, maximum rate of rise of left ventricular pressure; LV, left ventricle; LVEDP, left ventricular end-diastolic pressure; LVESP, left ventricular end-systolic pressure; LVP, left ventricular pressure; LVV, lentiviral vector; MI, myocardial infarction; VNS, vagus nerve stimulation; autonomic nervous system; eGFP, enhanced green fluorescent protein; heart failure; myocardial infarction; neuromodulation; vagus nerve stimulation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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