The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB<sub>1</sub> Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations.

Alexandre, João; Malheiro, Rui; Dias da Silva, Diana; Carmo, Helena; Carvalho, Félix; Silva, João Pedro

The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB₁ Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations.

Alexandre, João; Malheiro, Rui; Dias da Silva, Diana; Carmo, Helena; Carvalho, Félix; Silva, João Pedro.

Afiliación

Alexandre J; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Malheiro R; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Dias da Silva D; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Carmo H; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Carvalho F; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Silva JP; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

Int J Mol Sci ; 21(17)2020 Aug 30.

Article en En | MEDLINE | ID: mdl-32872617

Asunto(s)

Agonistas de Receptores de Cannabinoides/farmacología; Diferenciación Celular; Glioma/patología; Indazoles/farmacología; Indoles/farmacología; Naftalenos/farmacología; Neuroblastoma/patología; Quinolinas/farmacología; Receptor Cannabinoide CB1/metabolismo; Animales; Supervivencia Celular; Glioma/tratamiento farmacológico; Glioma/metabolismo; Ratones; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Neuroblastoma/tratamiento farmacológico; Neuroblastoma/metabolismo; Ratas; Células Tumorales Cultivadas

Palabras clave

developmental neurotoxicity; endocannabinoid system; neurogenesis; new psychoactive substances; substances of abuse

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolinas / Diferenciación Celular / Receptor Cannabinoide CB1 / Agonistas de Receptores de Cannabinoides / Glioma / Indazoles / Indoles / Naftalenos / Neuroblastoma Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Suiza

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