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Prediction of Results of Radiotherapy With Ku70 Expression and an Artificial Neural Network.
Hasegawa, Tomokazu; Someya, Masanori; Hori, Masakazu; Tsuchiya, Takaaki; Fukushima, Yuuki; Matsumoto, Yoshihisa; Sakata, Koh-Ichi.
Afiliación
  • Hasegawa T; Department of Radiation Oncology, Sapporo Medical University School of Medicine, Sapporo, Japan hasse@sapmed.ac.jp.
  • Someya M; Department of Radiation Oncology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Hori M; Department of Radiation Oncology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Tsuchiya T; Department of Radiation Oncology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Fukushima Y; Department of Radiation Oncology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Matsumoto Y; Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, Tokyo, Japan.
  • Sakata KI; Department of Radiation Oncology, Sapporo Medical University School of Medicine, Sapporo, Japan.
In Vivo ; 34(5): 2865-2872, 2020.
Article en En | MEDLINE | ID: mdl-32871826
Background/Aim: Accurate prediction of radiotherapy results is indispensable for the individualized selection of treatment modalities of cancer. We examined the application of the artificial neural network (ANN) model in predicting radiotherapy results using clinical factors and immunohistochemical staining of Ku70 as inputs. Patients and Methods: We analyzed 79 prostate cancer patients with localized adenocarcinoma treated with radiotherapy between August 2001 and October 2010. We also analyzed 46 hypopharyngeal cancer patients with squamous cell carcinoma treated with radiotherapy between March 2002 and December 2009. The properly trained ANN analysis using a standard feedforward, back-propagation neural network was used to predict the radiotherapy treatment results. Results: The areas under the receiver-operating characteristic curve (AUC) were 0.939 for patients treated with intensity modulated radiotherapy (IMRT)+androgen deprivation therapy (ADT), 0.803 for IMRT alone, and 0.960 for 3D-conformal radiotherapy (CRT) alone in prostate cancer. Sensitivity and specificity were 85.7% and 90.4% for IMRT+ADT, 75.0% and 88.5% for IMRT alone, and 92.3% and 100% for 3D-CRT alone. The AUC was 0.901 for hypopharyngeal cancer. Sensitivity and specificity were 66.7% and 88.2%, respectively. Conclusion: We demonstrated a possibility to predict the radiotherapy treatment results in prostate and hypopharyngeal cancer using ANN in combination with Ku70 expression and clinical factors as inputs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Radioterapia Conformacional / Radioterapia de Intensidad Modulada Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Radioterapia Conformacional / Radioterapia de Intensidad Modulada Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia