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Lower urinary tract function in frontotemporal lobar degeneration: A preliminary observation.
Sakakibara, Ryuji; Shimizu, Ayami; Takahashi, Osamu; Aiba, Yosuke; Tateno, Fuyuki; Sugisaki, Yuuka; Suzuki, Hiroyoshi; Yamamoto, Tatsuya; Uchiyama, Tomoyuki; Yamanishi, Tomonori.
Afiliación
  • Sakakibara R; Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan. Electronic address: sakakibara@sakura.med.toho-u.ac.jp.
  • Shimizu A; Clinical Physiology Unit, Sakura Medical Center, Toho University, Sakura, Japan.
  • Takahashi O; Clinical Physiology Unit, Sakura Medical Center, Toho University, Sakura, Japan.
  • Aiba Y; Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.
  • Tateno F; Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.
  • Sugisaki Y; Urology, Sakura Medical Center, Toho University, Sakura, Japan.
  • Suzuki H; Urology, Sakura Medical Center, Toho University, Sakura, Japan.
  • Yamamoto T; Neurology, Chiba Prefectural University of Health Sciences, Chiba, Japan.
  • Uchiyama T; Neurology, International University of Health and Welfare, Narita, Japan.
  • Yamanishi T; Continence Center, Dokkyo Medical College, Tochigi, Japan.
Auton Neurosci ; 229: 102719, 2020 12.
Article en En | MEDLINE | ID: mdl-32871389
OBJECTIVE: The urodynamics underlying lower urinary tract (LUT) dysfunction in frontotemporal lobar degeneration (FTLD) has not been reported. Herein, we investigated LUT function in FTLD patients by performing a urodynamics analysis. PATIENTS AND METHODS: We recruited five FTLD patients with LUT symptoms: three men, two women; mean age, 70.4 years; mean disease duration, 3.8 years; mean Hoehn-Yahr grade 1.0. We administered a urinary symptom questionnaire and performed a urodynamics study in each patient. RESULTS: LUT symptoms were observed in all patients. Urinary urgency/frequency (also called overactive bladder, OAB) was noted in all; OAB wet in three (60%) and mild voiding difficulty in two (40%). The urodynamic abnormalities included detrusor overactivity in four (80%), increased bladder sensation in two, large post-void residual in one (comorbid spondylosis), and latent detrusor underactivity in two. None had apparent outlet obstruction or detrusor-sphincter dyssynergia. Sphincter electromyography was normal in the cases studied. CONCLUSION: We observed detrusor overactivity in FTLD patients with LUT symptoms. Although a preliminary observation, this LUT feature, which might reflect the frontal/insular cortex pathology typically associated with FTLD, requires appropriate management and care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Autónomo / Incontinencia Urinaria / Vejiga Urinaria Hiperactiva / Degeneración Lobar Frontotemporal Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Auton Neurosci Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Autónomo / Incontinencia Urinaria / Vejiga Urinaria Hiperactiva / Degeneración Lobar Frontotemporal Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Auton Neurosci Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos