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Night shift work and immune response to the meningococcal conjugate vaccine in healthy workers: a proof of concept study.
Ruiz, Francieli S; Rosa, Daniela S; Zimberg, Ioná Z; Dos Santos Quaresma, Marcus Vl; Nunes, Jethe Of; Apostolico, Juliana S; Weckx, Lily Y; Souza, Alessandra R; Narciso, Fernanda V; Fernandes-Junior, Silvio A; Gonçalves, Bruno; Folkard, Simon; Bittencourt, Lia; Tufik, Sergio; Tulio de Mello, Marco.
Afiliación
  • Ruiz FS; Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK. Electronic address: francieliruizs@gmail.com.
  • Rosa DS; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Zimberg IZ; Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Dos Santos Quaresma MV; Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Nunes JO; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Apostolico JS; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Weckx LY; Departamento de Pediatria, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Souza AR; Departamento de Pediatria, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Narciso FV; Escola de Educação Física, Fisioterapia e Terapia Ocupacional (EEFFTO), Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Fernandes-Junior SA; Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Gonçalves B; Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, Brazil.
  • Folkard S; Department of Psychology, Swansea University, UK.
  • Bittencourt L; Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Tufik S; Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Tulio de Mello M; Escola de Educação Física, Fisioterapia e Terapia Ocupacional (EEFFTO), Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Sleep Med ; 75: 263-275, 2020 11.
Article en En | MEDLINE | ID: mdl-32866895
BACKGROUND: It is well-established that sleep regulates immune functions. Immunological functions are dependent on circadian rhythms and regular sleep as both have an impact on the magnitude of immune responses following antigenic challenge (eg, in vaccination). Here we investigated whether nocturnal shift work can influence post-vaccination response. METHODS: Thirty-four healthy workers (23 females) working either nocturnal or diurnal shifts (17 in each group) received the meningococcal C meningitis vaccine. Sleep was recorded polysomnographically (PSG) and with actigraphy. Humoral and cellular responses were assessed after vaccination. RESULTS: Night workers showed decreased N3 stage and REM sleep duration, increased inflammatory mediators (TNF-α and IL-6 levels), and a weak specific humoral response to vaccination associated with reduced CD4 T lymphocytes, reduced plasmacytoid dendritic cells, reduced prolactin levels, increased TReg and increased IL-10 levels. In addition, the decrease in total sleep time and circadian rhythm alterations were associated with a reduced humoral response post-vaccination. CONCLUSIONS: Our findings provide novel evidence concerning immune alterations of shift work on workers' health based on real-life circumstances. In association with circadian components, sufficient sleep time and rhythm synchronization were important for the development of the Ag-specific immune response, suggesting that the humoral response to vaccination may be impaired in individuals with chronic sleep restriction and circadian misalignment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Horario de Trabajo por Turnos Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Horario de Trabajo por Turnos Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos