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Detection of living cervical cancer cells by transient terahertz spectroscopy.
Shi, Wei; Wang, Yuezheng; Hou, Lei; Ma, Cheng; Yang, Lei; Dong, Chengang; Wang, Zhiquan; Wang, Haiqing; Guo, Juan; Xu, Shenglong; Li, Jing.
Afiliación
  • Shi W; Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an, China.
  • Wang Y; Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an, China.
  • Hou L; Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an, China.
  • Ma C; Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an, China.
  • Yang L; Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an, China.
  • Dong C; Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an, China.
  • Wang Z; Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an, China.
  • Wang H; Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an, China.
  • Guo J; Department of Military Preventive Medicine, The fourth military Medical University, Xi'an, China.
  • Xu S; Department of Military Preventive Medicine, The fourth military Medical University, Xi'an, China.
  • Li J; Department of Military Preventive Medicine, The fourth military Medical University, Xi'an, China.
J Biophotonics ; 14(1): e202000237, 2021 01.
Article en En | MEDLINE | ID: mdl-32864849
The photonic energy of terahertz wave is in the same order of magnitude as the rotational and vibrational energy levels of organic and biological macromolecules, so it has unique advantages in detecting cells and biological macromolecules. However, in the life environment, the dynamic time scale of cell-environment interaction and structural conformation change of biological macromolecules are within picosecond to millisecond, and water has strong absorption to terahertz wave, which has become the bottleneck problem for the detection of cells and biological macromolecules by terahertz technology. In this article, we developed a set of terahertz single measurement system based on the tilt wave front of grating pulse technique. The system was employed for the terahertz detection of trace living cervical cancer cells. We achieved transient detection of the terahertz pulse time-domain waveform of the living HeLa cells. The characteristic absorption peaks were identified by Lambert-Beer law, respectively, at 0.49, 0.71, 1.04, 1.07, 1.26 and 1.37 THz. The absorbance is proportional to the cell concentration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Espectroscopía de Terahertz Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: J Biophotonics Asunto de la revista: BIOFISICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Espectroscopía de Terahertz Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: J Biophotonics Asunto de la revista: BIOFISICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania