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Common and gender-specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group.
Rabin, Rachel A; Mackey, Scott; Parvaz, Muhammad A; Cousijn, Janna; Li, Chiang-Shan; Pearlson, Godfrey; Schmaal, Lianne; Sinha, Rajita; Stein, Elliot; Veltman, Dick; Thompson, Paul M; Conrod, Patricia; Garavan, Hugh; Alia-Klein, Nelly; Goldstein, Rita Z.
Afiliación
  • Rabin RA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Mackey S; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA.
  • Parvaz MA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Cousijn J; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Li CS; Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.
  • Pearlson G; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Schmaal L; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Sinha R; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia and Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
  • Stein E; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Veltman D; Intramural Research Program-Neuroimaging Research Branch, National Institute on Drug Abuse, Baltimore, Maryland, USA.
  • Thompson PM; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
  • Conrod P; Imaging Genetics Center, Department of Neurology Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
  • Garavan H; Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montreal, Quebec, Canada.
  • Alia-Klein N; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA.
  • Goldstein RZ; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hum Brain Mapp ; 43(1): 543-554, 2022 01.
Article en En | MEDLINE | ID: mdl-32857473
Gray matter volume (GMV) in frontal cortical and limbic regions is susceptible to cocaine-associated reductions in cocaine-dependent individuals (CD) and is negatively associated with duration of cocaine use. Gender differences in CD individuals have been reported clinically and in the context of neural responses to cue-induced craving and stress reactivity. The variability of GMV in select brain areas between men and women (e.g., limbic regions) underscores the importance of exploring interaction effects between gender and cocaine dependence on brain structure. Therefore, voxel-based morphometry data derived from the ENIGMA Addiction Consortium were used to investigate potential gender differences in GMV in CD individuals compared to matched controls (CTL). T1-weighted MRI scans and clinical data were pooled from seven sites yielding 420 gender- and age-matched participants: CD men (CDM, n = 140); CD women (CDW, n = 70); control men (CTLM, n = 140); and control women (CTLW, n = 70). Differences in GMV were assessed using a 2 × 2 ANCOVA, and voxelwise whole-brain linear regressions were conducted to explore relationships between GMV and duration of cocaine use. All analyses were corrected for age, total intracranial volume, and site. Diagnostic differences were predominantly found in frontal regions (CD < CTL). Interestingly, gender × diagnosis interactions in the left anterior insula and left lingual gyrus were also documented, driven by differences in women (CDW < CTLW). Further, lower right hippocampal GMV was associated with greater cocaine duration in CDM. Given the importance of the anterior insula to interoception and the hippocampus to learning contextual associations, results may point to gender-specific mechanisms in cocaine addiction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Corteza Cerebral / Caracteres Sexuales / Trastornos Relacionados con Cocaína / Neuroimagen / Sustancia Gris Tipo de estudio: Clinical_trials / Risk_factors_studies / Systematic_reviews Aspecto: Determinantes_sociais_saude Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Corteza Cerebral / Caracteres Sexuales / Trastornos Relacionados con Cocaína / Neuroimagen / Sustancia Gris Tipo de estudio: Clinical_trials / Risk_factors_studies / Systematic_reviews Aspecto: Determinantes_sociais_saude Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos