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Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging.
Ma, Ke; Cheng, Yongbin; Wei, Xinran; Chen, Daijun; Zhao, Xiaoli; Jia, Pengxiang.
Afiliación
  • Ma K; Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of chemistry and materials science, 12657Northwest University, Xi'an, Shaanxi, China.
  • Cheng Y; Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of chemistry and materials science, 12657Northwest University, Xi'an, Shaanxi, China.
  • Wei X; Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of chemistry and materials science, 12657Northwest University, Xi'an, Shaanxi, China.
  • Chen D; Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of chemistry and materials science, 12657Northwest University, Xi'an, Shaanxi, China.
  • Zhao X; Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of chemistry and materials science, 12657Northwest University, Xi'an, Shaanxi, China.
  • Jia P; Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of chemistry and materials science, 12657Northwest University, Xi'an, Shaanxi, China.
J Biomater Appl ; 35(7): 857-868, 2021 02.
Article en En | MEDLINE | ID: mdl-32854570
In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a narrow distribution. The size of the Au@CS-PMPC NPs, as well as the size of the embedded gold NPs, might be well-controlled by adjusting the feeding ratio between chitosan and HAuCl4. Furthermore, the Au@CS-PMPC NPs showed increased colloidal stability, high drug loading content, pH-responsive drug release, excellent biocompatibility and bright fluorescence emission. The results demonstrated that Au@CS-PMPC NPs showed a great potential for tumor therapy via the combination advantages of pH-sensitive controlled drug release and cellular fluorescence imaging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Membrana Celular / Sistemas de Liberación de Medicamentos / Quitosano / Nanopartículas / Oro Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Membrana Celular / Sistemas de Liberación de Medicamentos / Quitosano / Nanopartículas / Oro Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido