Your browser doesn't support javascript.
loading
Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities.
Abu-Darwish, Mohammad Sanad; Cabral, Célia; Ali, Zulfigar; Wang, Mei; Khan, Shabana I; Jacob, Melissa R; Jain, Surendra K; Tekwani, Babu L; Zulfiqar, Fazila; Khan, Ikhlas A; Taifour, Hatem; Salgueiro, Lígia; Efferth, Thomas.
Afiliación
  • Abu-Darwish MS; Department of Basic and Applied Sciences, Al-Balqa Applied University, Al-Salt, 19117, Jordan.
  • Cabral C; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
  • Ali Z; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548, Coimbra, Portugal. celia.cabral@fmed.uc.pt.
  • Wang M; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548, Coimbra, Portugal. celia.cabral@fmed.uc.pt.
  • Khan SI; Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal. celia.cabral@fmed.uc.pt.
  • Jacob MR; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
  • Jain SK; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
  • Tekwani BL; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
  • Zulfiqar F; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
  • Khan IA; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
  • Taifour H; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
  • Salgueiro L; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
  • Efferth T; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
Nat Prod Bioprospect ; 10(5): 307-316, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32852722
In Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it's predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC50 between 60 and > 100 µg/mL. The EO inhibited NO production (IC50 90 µg/mL) and NF-κB activity (IC50 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC50 between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC50 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC50 2.65 µg/mL. In conclusion, Jordan S. ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Bioprospect Año: 2020 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Bioprospect Año: 2020 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Alemania