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Synthesis and Biological Studies on Dinuclear Gold(I) Complexes with Di-(N-Heterocyclic Carbene) Ligands Functionalized with Carbohydrates.
Tresin, Federica; Stoppa, Valentina; Baron, Marco; Biffis, Andrea; Annunziata, Alfonso; D'Elia, Luigi; Monti, Daria Maria; Ruffo, Francesco; Roverso, Marco; Sgarbossa, Paolo; Bogialli, Sara; Tubaro, Cristina.
Afiliación
  • Tresin F; Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
  • Stoppa V; Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
  • Baron M; Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
  • Biffis A; Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
  • Annunziata A; Department of Chemical Sciences, University of Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cintia 21, 80126 Napoli, Italy.
  • D'Elia L; Department of Chemical Sciences, University of Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cintia 21, 80126 Napoli, Italy.
  • Monti DM; Department of Chemical Sciences, University of Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cintia 21, 80126 Napoli, Italy.
  • Ruffo F; Department of Chemical Sciences, University of Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cintia 21, 80126 Napoli, Italy.
  • Roverso M; Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
  • Sgarbossa P; Department of Industrial Engineering, University of Padova, via Marzolo 9, 35131 Padova, Italy.
  • Bogialli S; Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
  • Tubaro C; Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
Molecules ; 25(17)2020 Aug 24.
Article en En | MEDLINE | ID: mdl-32847116
The design of novel metal complexes with N-heterocyclic carbene (NHC) ligands that display biological activity is an active research field in organometallic chemistry. One of the possible approaches consists of the use of NHC ligands functionalized with a carbohydrate moiety. Two novel Au(I)-Au(I) dinuclear complexes were synthesized; they present a neutral structure with one bridging diNHC ligand, having one or both heterocyclic rings decorated with a carbohydrate functionality. With the symmetric diNHC ligand, the dicationic dinuclear complex bearing two bridging diNHC ligands was also synthesized. The study was completed by analyzing the antiproliferative properties of these complexes, which were compared to the activity displayed by similar mononuclear Au(I) complexes and by the analogous bimetallic Au(I)-Au(I) complex not functionalized with carbohydrates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proliferación Celular / Compuestos Orgánicos de Oro / Oro / Compuestos Heterocíclicos / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proliferación Celular / Compuestos Orgánicos de Oro / Oro / Compuestos Heterocíclicos / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza