Decoding the rosetta stone of mitonuclear communication.

English, Justin; Son, Jyung Mean; Cardamone, Maria Dafne; Lee, Changhan; Perissi, Valentina

English, Justin; Son, Jyung Mean; Cardamone, Maria Dafne; Lee, Changhan; Perissi, Valentina.

Afiliación

English J; Department of Biochemistry, Boston University, Boston, MA, 02115, USA; Graduate Program in Biomolecular Pharmacology, Department of Pharmacology and Experimental Therapeutics, Boston University, Boston, MA, 02115, USA.
Son JM; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Cardamone MD; Department of Biochemistry, Boston University, Boston, MA, 02115, USA.
Lee C; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; USC Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA; Biomedical Sciences, Graduate School, Ajou University, Suwon, 16499, South Korea.
Perissi V; Department of Biochemistry, Boston University, Boston, MA, 02115, USA. Electronic address: vperissi@bu.edu.

Pharmacol Res ; 161: 105161, 2020 11.

Article en En | MEDLINE | ID: mdl-32846213

RESUMEN

Cellular homeostasis in eukaryotic cells requires synchronized coordination of multiple organelles. A key role in this stage is played by mitochondria, which have recently emerged as highly interconnected and multifunctional hubs that process and coordinate diverse cellular functions. Beyond producing ATP, mitochondria generate key metabolites and are central to apoptotic and metabolic signaling pathways. Because most mitochondrial proteins are encoded in the nuclear genome, the biogenesis of new mitochondria and the maintenance of mitochondrial functions and flexibility critically depend upon effective mitonuclear communication. This review addresses the complex network of signaling molecules and pathways allowing mitochondria-nuclear communication and coordinated regulation of their independent but interconnected genomes, and discusses the extent to which dynamic communication between the two organelles has evolved for mutual benefit and for the overall maintenance of cellular and organismal fitness.

Asunto(s)

Comunicación Celular; Núcleo Celular/metabolismo; Mitocondrias/metabolismo; Proteínas Mitocondriales/metabolismo; Proteínas Nucleares/metabolismo; Animales; Núcleo Celular/genética; Regulación de la Expresión Génica; Humanos; Mitocondrias/genética; Proteínas Mitocondriales/genética; Proteínas Nucleares/genética; Transducción de Señal

Palabras clave

Acetyl-Coenzyme A (PubChem CID: 6302); Alpha-ketoglutarate (PubChem CID: 164533); Antimycin (PubChem CID: 12550); Carbonyl cyanide m-chlorophenylhydrazone (CCCP) (PubChem CID: 2603); Communication; Epigenetics; Humanin (PubChem CID: 16131438); Integrated stress response; Mitochondrial retrograde signaling; Mitonuclear; Nicotinamide riboside (PubChem CID: 439924); Oligoymycin (PubChem CID: 78358496); S-adenosylmethionine (SAM) (PubChem CID: 34756); Superoxide anion (PubChem CID: 5359597)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Comunicación Celular / Núcleo Celular / Proteínas Mitocondriales / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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