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The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis.
Graceli, Jones B; Dettogni, Raquel S; Merlo, Eduardo; Niño, Oscar; da Costa, Charles S; Zanol, Jordana F; Ríos Morris, Eduardo A; Miranda-Alves, Leandro; Denicol, Anna C.
Afiliación
  • Graceli JB; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo. Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: jbgraceli@gmail.com.
  • Dettogni RS; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo. Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: raquel.dettogni@ufes.br.
  • Merlo E; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo. Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: edu.merlo92@gmail.com.
  • Niño O; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo. Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: oscarsantamaria8@hotmail.com.
  • da Costa CS; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo. Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: chsantoscosta@hotmail.com.
  • Zanol JF; Department of Morphology, Health Sciences Center, Federal University of Espirito Santo. Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address: jozanol@hotmail.com.
  • Ríos Morris EA; Laboratory of Experimental Endocrinology-LEEx, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil. Graduate Program in Endocrinology, Faculty of Medicine, Federal University of Rio de Janeiro, Brazil. Electronic address: grujula@gmail.com.
  • Miranda-Alves L; Laboratory of Experimental Endocrinology-LEEx, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil. Graduate Program in Endocrinology, Faculty of Medicine, Federal University of Rio de Janeiro, Brazil. Graduate Program in Pharmacology and Medicinal Chemistry, Institute of
  • Denicol AC; Department of Animal Science, University of California, Davis, One Shields Avenue Davis, CA, 95616, USA. Electronic address: acdenicol@ucdavis.edu.
Mol Cell Endocrinol ; 518: 110997, 2020 12 01.
Article en En | MEDLINE | ID: mdl-32841708
The hypothalamic-pituitary axis (HP axis) plays a critical and integrative role in the endocrine system control to maintain homeostasis. The HP axis is responsible for the hormonal events necessary to regulate the thyroid, adrenal glands, gonads, somatic growth, among other functions. Endocrine-disrupting chemicals (EDCs) are a worldwide public health concern. There is growing evidence that exposure to EDCs such as bisphenol A (BPA), some phthalates, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and biphenyls (PBBs), dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and atrazine (ATR), is associated with HP axis abnormalities. EDCs act on hormone receptors and their downstream signaling pathways and can interfere with hormone synthesis, metabolism, and actions. Because the HP axis function is particularly sensitive to endogenous hormonal changes, disruptions by EDCs can alter HP axis proper function, leading to important endocrine irregularities. Here, we review the evidence that EDCs could directly affect the mammalian HP axis function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disruptores Endocrinos / Sistema Hipotálamo-Hipofisario Límite: Animals / Humans Idioma: En Revista: Mol Cell Endocrinol Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disruptores Endocrinos / Sistema Hipotálamo-Hipofisario Límite: Animals / Humans Idioma: En Revista: Mol Cell Endocrinol Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda