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Histopathological findings in fatal COVID-19 severe acute respiratory syndrome: preliminary experience from a series of 10 Spanish patients.
Recalde-Zamacona, Borja; García-Tobar, Laura; Argueta, Alan; Álvarez, Laura; De Andrea, Carlos Eduardo; Fernández Alonso, Mirian; Ezponda, Ana; Carmona Torre, Francisco; Jordán Iborra, Carlota; Quiroga, Jorge Augusto; Del Pozo, Jose Luis; Zulueta, Javier J; Echarri, Gema; Landecho, Manuel F; Lozano, Maria Dolores.
Afiliación
  • Recalde-Zamacona B; Service of Pulmonary Medicine, Clinica Universitaria, Pamplona, Spain.
  • García-Tobar L; Covid19 Department, Clinica UNiversidad de Navarra, Pamplona, Navarra, Spain.
  • Argueta A; Pathology, University of Navarra, Pamplona, Navarra, Spain.
  • Álvarez L; Pathology, University of Navarra, Pamplona, Navarra, Spain.
  • De Andrea CE; Pathology, University of Navarra, Pamplona, Navarra, Spain.
  • Fernández Alonso M; Pathology, University of Navarra, Pamplona, Navarra, Spain.
  • Ezponda A; Microbiology and infectious diseases, Clinica Universidad de Navarra, Pamplona, Spain.
  • Carmona Torre F; Radiology, Clinica Universitaria de Navarra, Pamplona, Spain.
  • Jordán Iborra C; Covid19 Department, Clinica UNiversidad de Navarra, Pamplona, Navarra, Spain.
  • Quiroga JA; Microbiology and infectious diseases, Clinica Universidad de Navarra, Pamplona, Spain.
  • Del Pozo JL; Covid19 Department, Clinica UNiversidad de Navarra, Pamplona, Navarra, Spain.
  • Zulueta JJ; Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
  • Echarri G; Covid19 Department, Clinica UNiversidad de Navarra, Pamplona, Navarra, Spain.
  • Landecho MF; Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
  • Lozano MD; CIBEREHD, CIBER, Pamplona, Spain.
Thorax ; 75(12): 1116-1118, 2020 12.
Article en En | MEDLINE | ID: mdl-32839288
In December 2019, an outbreak of severe acute respiratory syndrome associated to SARS-CoV2 was reported in Wuhan, China. To date, little is known on histopathological findings in patients infected with the new SARS-CoV2. Lung histopathology shows features of acute and organising diffuse alveolar damage. Subtle cellular inflammatory infiltrate has been found in line with the cytokine storm theory. Medium-size vessel thrombi were frequent, but capillary thrombi were not present. Despite the elevation of biochemical markers of cardiac injury, little histopathological damage could be confirmed. Viral RNA from paraffin sections was detected at least in one organ in 90% patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Pandemias / SARS-CoV-2 / COVID-19 / Pulmón Tipo de estudio: Diagnostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Thorax Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Pandemias / SARS-CoV-2 / COVID-19 / Pulmón Tipo de estudio: Diagnostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Thorax Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido