Faecal cytokine profiling as a marker of intestinal inflammation in acutely decompensated cirrhosis.

Riva, Antonio; Gray, Elizabeth H; Azarian, Sarah; Zamalloa, Ane; McPhail, Mark J W; Vincent, Royce P; Williams, Roger; Chokshi, Shilpa; Patel, Vishal C; Edwards, Lindsey A

Riva, Antonio; Gray, Elizabeth H; Azarian, Sarah; Zamalloa, Ane; McPhail, Mark J W; Vincent, Royce P; Williams, Roger; Chokshi, Shilpa; Patel, Vishal C; Edwards, Lindsey A.

Afiliación

Riva A; Institute of Hepatology London, Foundation for Liver Research, London, UK.
Gray EH; School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Azarian S; Institute of Hepatology London, Foundation for Liver Research, London, UK.
Zamalloa A; School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
McPhail MJW; Institute of Hepatology London, Foundation for Liver Research, London, UK.
Vincent RP; School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Williams R; Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK.
Chokshi S; School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Patel VC; Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK.
Edwards LA; Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK.

JHEP Rep ; 2(6): 100151, 2020 Dec.

Article en En | MEDLINE | ID: mdl-32838247

Palabras clave

ACLF, acute-on-chronic liver failure; AD, acute decompensation; AUROC, area under the receiver operating characteristic; BT, bacterial translocation; Bacterial translocation; CLIF-C AD, Chronic Liver Failure Consortium-acute decompensation; Chronic liver disease; Cytokines; DS, discriminant score; FABP2, fatty-acid-binding protein-2; FCAL, faecal calprotectin; FDR, false discovery rate; FL, faecal lysate; FWER, family-wise error rate; GVB, gut vascular barrier; Gut inflammation; HC, healthy control; IBD, inflammatory bowel disease; IEC, intestinal epithelial cell; Intestinal barrier function; MELD, model for end-stage liver disease; OPLS-DA, orthogonal projection to latent structures discriminant analysis; PAMP, pathogen-associated molecular pattern; PCA, principal component analysis; ROC, receiver operating characteristic; SC, stable cirrhosis; UKELD, United Kingdom model for end-stage liver disease

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: JHEP Rep Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Países Bajos

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