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Do all antiphospholipid antibodies confer the same risk for major organ involvement in systemic lupus erythematosus patients?
Riancho-Zarrabeitia, Leyre; Martínez-Taboada, Víctor M; Rúa-Figueroa, Iñigo; Alonso, Fernando; Galindo-Izquierdo, María; Ovalles, Juan; Olivé-Marqués, Alejandro; Mena Vázquez, Natalia; Calvo-Alén, Jaime; Menor Almagro, Raúl; Tomero Muriel, Eva; Uriarte Isacelaya, Esther; Boteanu, Alina; Andres, Mariano; Freire González, Mercedes; Santos Soler, Gregorio; Ruiz-Lucea, Maria Esther; Ibáñez-Barceló, Mónica; Castellví, Iván; Galisteo, Carlos; Quevedo Vila, Víctor; Raya, Enrique; Narváez, Javier; Expósito, Lorena; Hernández Beriaín, José A; Horcada, Loreto; Aurrecoechea, Elena; Pego Reigosa, José M.
Afiliación
  • Riancho-Zarrabeitia L; Rheumatology Department, Hospital Sierrallana, IDIVAL, Torrelavega, Spain.
  • Martínez-Taboada VM; Rheumatology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Spain. vmartinezt64@gmail.com.
  • Rúa-Figueroa I; Rheumatology Department, Hospital Universitario Doctor Negrín, Las Palmas, Spain.
  • Alonso F; Unidad de Investigación, Sociedad Española de Reumatología, Madrid, Spain.
  • Galindo-Izquierdo M; Rheumatology Department, Hospital Universitario Doce de Octubre, Madrid, Spain.
  • Ovalles J; Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Olivé-Marqués A; Rheumatology Department, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain.
  • Mena Vázquez N; Rheumatology Department, Hospital Regional Universitario de Málaga, Spain.
  • Calvo-Alén J; Rheumatology Department, Hospital Universitario Araba, Álava, Spain.
  • Menor Almagro R; Rheumatology Department, Hospital de Jerez, Cádiz, Spain.
  • Tomero Muriel E; Rheumatology Department, Hospital Universitario La Princesa, Madrid, Spain.
  • Uriarte Isacelaya E; Rheumatology Department, Hospital Universitario Donosti, San Sebastián, Spain.
  • Boteanu A; Rheumatology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Andres M; Rheumatology Department, Hospital General Universitario de Alicante, Spain.
  • Freire González M; Rheumatology Department, Hospital Universitario Juan Canalejo, A Coruña, Spain.
  • Santos Soler G; Rheumatology Department, Hospital Marina Baixa, Alicante, Spain.
  • Ruiz-Lucea ME; Rheumatology Department, Hospital Universitario Basurto, Bilbao, Spain.
  • Ibáñez-Barceló M; Rheumatology Department, Hospital Universitario Son Llàtzer, Palma, Spain.
  • Castellví I; Rheumatology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Galisteo C; Rheumatology Department, Hospital Universitario Parc Taulí, Barcelona, Spain.
  • Quevedo Vila V; Rheumatology Department, Hospital Comarcal Monforte, Lugo, Spain.
  • Raya E; Rheumatology Department, Hospital Universitario Clínico San Cecilia, Granada, Spain.
  • Narváez J; Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain.
  • Expósito L; Rheumatology Department, Hospital Universitario Canaries, Tenerife, Spain.
  • Hernández Beriaín JA; Rheumatology Department, Hospital Insular Universitario de Gran Canaria, Las Palmas, Spain.
  • Horcada L; Rheumatology Department, Complejo Hospitalario Universitario de Navarra, Spain.
  • Aurrecoechea E; Rheumatology Department, Hospital Sierrallana, IDIVAL, Torrelavega, Spain.
  • Pego Reigosa JM; Complejo Hospitalario Universitario de Vigo IRIDIS Group, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Vigo, Spain.
Clin Exp Rheumatol ; 39(3): 555-563, 2021.
Article en En | MEDLINE | ID: mdl-32828148
OBJECTIVES: We aimed to investigate the association between the different antiphospholipid antibodies (aPL) and both systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) manifestations. METHODS: Patients from the RELESSER registry, a Spanish retrospective, cross-sectional, forty-five hospital registry of adult SLE patients, were included. RESULTS: Out of a total of 3,658 SLE patients, 1372 were aPL positive (555 of them fulfilled criteria for APS). All aPL types showed a negative association with cutaneous SLE manifestations. Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) were both associated with haematological, ophthalmological and neuropsychiatric manifestations. IgG isotypes were associated with a higher risk of lupus manifestations compared with IgM. We found that the risk of neuropsychiatric and ophthalmological manifestations significantly increased with a higher number of positive aPL whereas the risk of cutaneous symptoms showed a negative correlation. All types of aPL, and more strongly LA, were associated with non-criteria antiphospholipid syndrome (APS) manifestations such as thrombocytopenia and haemolytic anaemia. Moreover, LA and aCL (particularly IgG isotype) were also associated with Libman-Sacks endocarditis and cognitive impairment. This association was stronger with more than one positive aPL. All types of aPL were also associated with classic APS manifestations, although LA, IgG isotypes, and patients with more than one aPL displayed a higher risk. CONCLUSIONS: There is a hierarchy for aPL and the risk of APS and SLE manifestations. aCL, and especially LA, confer a higher risk for major organ involvement in SLE. IgG isotypes seem to have a more important role. The load of aPL confer a higher risk for APS and certain SLE manifestations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Antifosfolípido / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Clin Exp Rheumatol Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Antifosfolípido / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Clin Exp Rheumatol Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia