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The Effect of Isoleucine Supplementation on Body Weight Gain and Blood Glucose Response in Lean and Obese Mice.
O'Rielly, Rebecca; Li, Hui; Lim, See Meng; Yazbeck, Roger; Kritas, Stamatiki; Ullrich, Sina S; Feinle-Bisset, Christine; Heilbronn, Leonie; Page, Amanda J.
Afiliación
  • O'Rielly R; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
  • Li H; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
  • Lim SM; Nutrition, Diabetes and Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA 5001, Australia.
  • Yazbeck R; School of Agriculture, Food and Wine, The University of Adelaide, Glen Osmond, SA 5064, Australia.
  • Kritas S; Centre for Community Health Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
  • Ullrich SS; College of Medicine and Public Health, Flinders Medical Centre, Flinders University, Bedford Park, SA 5042, Australia.
  • Feinle-Bisset C; Women's and Children's Hospital, North Adelaide, SA 5006, Australia.
  • Heilbronn L; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
  • Page AJ; Clinical Trial Unit, Department of Clinical Research, University of Basel and University Hospital Basel, 4031 Basel, Switzerland.
Nutrients ; 12(8)2020 Aug 14.
Article en En | MEDLINE | ID: mdl-32823899
Chronic isoleucine supplementation prevents diet-induced weight gain in rodents. Acute-isoleucine administration improves glucose tolerance in rodents and reduces postprandial glucose levels in humans. However, the effect of chronic-isoleucine supplementation on body weight and glucose tolerance in obesity is unknown. This study aimed to investigate the impact of chronic isoleucine on body weight gain and glucose tolerance in lean and high-fat-diet (HFD) induced-obese mice. Male C57BL/6-mice, fed a standard-laboratory-diet (SLD) or HFD for 12 weeks, were randomly allocated to: (1) Control: Drinking water; (2) Acute: Drinking water with a gavage of isoleucine (300 mg/kg) prior to the oral-glucose-tolerance-test (OGTT) or gastric-emptying-breath-test (GEBT); (3) Chronic: Drinking water with 1.5% isoleucine, for a further six weeks. At 16 weeks, an OGTT and GEBT was performed and at 17 weeks metabolic monitoring. In SLD- and HFD-mice, there was no difference in body weight, fat mass, and plasma lipid profiles between isoleucine treatment groups. Acute-isoleucine did not improve glucose tolerance in SLD- or HFD-mice. Chronic-isoleucine impaired glucose tolerance in SLD-mice. There was no difference in gastric emptying between any groups. Chronic-isoleucine did not alter energy intake, energy expenditure, or respiratory quotient in SLD- or HFD-mice. In conclusion, chronic isoleucine supplementation may not be an effective treatment for obesity or glucose intolerance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Delgadez / Glucemia / Aumento de Peso / Suplementos Dietéticos / Resultados Negativos / Isoleucina / Fenómenos Fisiológicos de la Nutrición / Obesidad Límite: Animals / Humans / Male Idioma: En Revista: Nutrients Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Delgadez / Glucemia / Aumento de Peso / Suplementos Dietéticos / Resultados Negativos / Isoleucina / Fenómenos Fisiológicos de la Nutrición / Obesidad Límite: Animals / Humans / Male Idioma: En Revista: Nutrients Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza