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The evolution of white matter microstructural changes after mild traumatic brain injury: A longitudinal DTI and NODDI study.
Palacios, E M; Owen, J P; Yuh, E L; Wang, M B; Vassar, M J; Ferguson, A R; Diaz-Arrastia, R; Giacino, J T; Okonkwo, D O; Robertson, C S; Stein, M B; Temkin, N; Jain, S; McCrea, M; MacDonald, C L; Levin, H S; Manley, G T; Mukherjee, P.
Afiliación
  • Palacios EM; Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, USA.
  • Owen JP; Department of Radiology, University of Washington, Seattle, WA, USA.
  • Yuh EL; Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, USA.
  • Wang MB; Brain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA.
  • Vassar MJ; Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, USA.
  • Ferguson AR; Brain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA.
  • Diaz-Arrastia R; Department of Neurological Surgery, UCSF, San Francisco, CA, USA.
  • Giacino JT; Brain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA.
  • Okonkwo DO; Department of Neurological Surgery, UCSF, San Francisco, CA, USA.
  • Robertson CS; San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Stein MB; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
  • Temkin N; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, MA, USA.
  • Jain S; Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.
  • McCrea M; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • MacDonald CL; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
  • Levin HS; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Manley GT; Department of Family Medicine & Public Health, University of California, San Diego, La Jolla, CA, USA.
  • Mukherjee P; Department of Neurological Surgery, University of Washington, Seattle, WA, USA.
Sci Adv ; 6(32): eaaz6892, 2020 08.
Article en En | MEDLINE | ID: mdl-32821816
Neuroimaging biomarkers that can detect white matter (WM) pathology after mild traumatic brain injury (mTBI) and predict long-term outcome are needed to improve care and develop therapies. We used diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) to investigate WM microstructure cross-sectionally and longitudinally after mTBI and correlate these with neuropsychological performance. Cross-sectionally, early decreases of fractional anisotropy and increases of mean diffusivity corresponded to WM regions with elevated free water fraction on NODDI. This elevated free water was more extensive in the patient subgroup reporting more early postconcussive symptoms. The longer-term longitudinal WM changes consisted of declining neurite density on NODDI, suggesting axonal degeneration from diffuse axonal injury for which NODDI is more sensitive than DTI. Therefore, NODDI is a more sensitive and specific biomarker than DTI for WM microstructural changes due to mTBI that merits further study for mTBI diagnosis, prognosis, and treatment monitoring.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Sci Adv Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Sci Adv Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos