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Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses.
Fries, Chelsea N; Wu, Yaoying; Kelly, Sean H; Wolf, Michelle; Votaw, Nicole L; Zauscher, Stefan; Collier, Joel H.
Afiliación
  • Fries CN; Department of Biomedical Engineering, 1316 FCIEMAS, 101 Science Dr, Durham, NC, 27708, USA.
  • Wu Y; Department of Biomedical Engineering, 1316 FCIEMAS, 101 Science Dr, Durham, NC, 27708, USA.
  • Kelly SH; Department of Biomedical Engineering, 1316 FCIEMAS, 101 Science Dr, Durham, NC, 27708, USA.
  • Wolf M; Department of Biomedical Engineering, 1316 FCIEMAS, 101 Science Dr, Durham, NC, 27708, USA.
  • Votaw NL; Department of Biomedical Engineering, 1316 FCIEMAS, 101 Science Dr, Durham, NC, 27708, USA.
  • Zauscher S; Department of Biomedical Engineering, 1316 FCIEMAS, 101 Science Dr, Durham, NC, 27708, USA.
  • Collier JH; Department of Mechanical Engineering and Materials Science, 3385 FCIEMAS, 101 Science Dr, Durham, NC, 27708, USA.
Adv Mater ; 32(39): e2003310, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32820582
Peptide nanofibers are useful for many biological applications, including immunotherapy, tissue engineering, and drug delivery. The robust lengthwise assembly of these peptides into nanofibers is typically difficult to control, resulting in polydisperse fiber lengths and an incomplete understanding of how nanofiber length affects biological responses. Here, rationally designed capping peptides control the length of helical peptide nanofibers with unique precision. These designed peptides bind the tips of elongated nanofibers to shorten and narrow their length distributions. Demonstrating their use as immunotherapies, capped nanofibers are preferentially cross-presented by dendritic cells compared to uncapped nanofibers. Due to increased cross-presentation, these capped nanofibers trigger stronger CD8+ T-cell responses in mice than uncapped nanofibers. This strategy illustrates a means for controlling the length of supramolecular peptide nanofibers to modulate their immunogenicity in the context of immunotherapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Linfocitos T CD8-positivos / Nanofibras / Factores Inmunológicos Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Linfocitos T CD8-positivos / Nanofibras / Factores Inmunológicos Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania