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Lymphatic invasion in acral and non-acral melanoma: a comparative, clinicoprognostic study of primary cutaneous melanoma according to tumour site.
Jung, Joon Min; Won, Chong Hyun; Chang, Sung Eun; Lee, Mi Woo; Choi, Jee Ho; Lee, Woo Jin.
Afiliación
  • Jung JM; Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Won CH; Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Chang SE; Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Lee MW; Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Choi JH; Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Lee WJ; Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address: uucm79@hanmail.net.
Pathology ; 52(6): 670-675, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32819739
There have been limited studies comparing the clinical significance of lymphatic invasion in melanoma according to tumour site. The objective of this study was to evaluate the impact of lymphatic invasion on the clinicoprognostic features of acral and non-acral melanoma. Clinical and histopathological features and survival outcomes of 532 patients with acral melanoma or non-acral melanoma in the database of the Asan Medical Center, Korea, were retrospectively evaluated according to the presence of lymphatic invasion. Lymphatic invasion was significantly more common in acral melanoma than non-acral melanoma. In acral melanoma, lymphatic invasion was significantly associated with a higher frequency of lymph node involvement and advanced stages, but not associated with Breslow thickness or visceral dissemination. By contrast, lymphatic invasion in non-acral melanoma was significantly associated with a higher rate of visceral involvement, deeper Breslow thickness, as well as a higher rate of lymph node involvement and advanced stages. When acral melanoma and non-acral melanoma both with lymphatic invasion were compared, Breslow thickness was significantly shallower and vertical growth phase was significantly less common in acral melanoma. Meanwhile, visceral involvement was significantly more frequent in non-acral melanoma than acral melanoma. In conclusion, lymphatic invasion was more common in acral melanoma than non-acral melanoma and occurred in acral melanoma cases with relatively thin Breslow thickness, suggesting acral melanoma is lymphotropic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Pathology Año: 2020 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Pathology Año: 2020 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido