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In vivo immune activation of splenocytes following exposure to tar from Asian sand dust.
Shen, Mengyue; Song, Yuan; Ichinose, Takamichi; Morita, Kentaro; Wang, Duo; Arashidani, Keiichi; Yoshida, Yasuhiro.
Afiliación
  • Shen M; Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health , Kitakyushu, Japan.
  • Song Y; Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health , Kitakyushu, Japan.
  • Ichinose T; Department of Clinical Laboratory, The Fourth Hospital of Hebei Medical University , Shijiazhuang, China.
  • Morita K; Department of Health Sciences, Oita University of Nursing and Health Sciences , Oita, Japan.
  • Wang D; Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health , Kitakyushu, Japan.
  • Arashidani K; Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health , Kitakyushu, Japan.
  • Yoshida Y; Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health , Kitakyushu, Japan.
J Toxicol Environ Health A ; 83(19-20): 649-658, 2020 10 17.
Article en En | MEDLINE | ID: mdl-32819208
Air pollution, especially that initiated by particulate matter (PM), has been implicated as a risk factor for several inflammatory diseases. Previously, it was reported that PM enhances immune responses. PM includes the tar fraction that contains polycyclic aromatic hydrocarbons (PAHs), which produce adverse health effects in exposed individuals. However, the influence of the tar fraction (as a component of PM) on splenocytes is not fully understood. The aim of this study was to determine the effects of the tar fraction extracted from PM collected from the atmosphere in Fukuoka, Japan, on mouse splenocytes. ICR mice were administered tar (1 or 5 µg/mouse) intratracheally 4 times at 2-week intervals, and splenocytes from the tar-treated mice were extracted and examined. The parameters determined were proliferation, cytokine concentrations and transcription factors activation. Following tar treatment, splenocyte proliferation increased relative to controls. Concanavalin A (ConA)-induced interleukin (IL)-2 formation and ConA- or lipopolysaccharide (LPS)-induced interferon-γ production were elevated in splenocytes from tar-exposed mice. However, the production of tumor necrosis factor-α and IL-6 induced by LPS was not markedly changed following tar treatment. Further, nuclear factor of activated T cells, but not nuclear factor-κB, was enhanced in splenocytes of tar-exposed mice. Data indicate that tar-activated splenocytes and PM-bound PAHs might contribute to T cell activation in the spleen.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocarburos Policíclicos Aromáticos / Bazo / Contaminantes Atmosféricos / Polvo / Material Particulado Tipo de estudio: Risk_factors_studies Límite: Animals País/Región como asunto: Asia Idioma: En Revista: J Toxicol Environ Health A Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocarburos Policíclicos Aromáticos / Bazo / Contaminantes Atmosféricos / Polvo / Material Particulado Tipo de estudio: Risk_factors_studies Límite: Animals País/Región como asunto: Asia Idioma: En Revista: J Toxicol Environ Health A Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido