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In Vitro Evaluation of a Fluorescent Microemulsion as an Oral Delivery Carrier and its Potential Application in Tracking Bioactive Compounds Label-Free.
Wang, Zhanzhong; Liu, Xiaoxue; Li, Qing; Qiu, Shuang; Wang, Xueping; Byambasuren, Khorolgarav; Liu, Zhengan; Dang, Leping; Shu, Qingyan.
Afiliación
  • Wang Z; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
  • Liu X; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
  • Li Q; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
  • Qiu S; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
  • Wang X; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
  • Byambasuren K; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
  • Liu Z; Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, China.
  • Dang L; School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
  • Shu Q; Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, China.
J Agric Food Chem ; 68(33): 8996-9003, 2020 Aug 19.
Article en En | MEDLINE | ID: mdl-32806119
In this work, a microemulsion emitting fluorescence was fabricated as a potential oral delivery system for bioactive compounds. In simulated oral administration, the microemulsion was characterized for its microstructure by 1hydrogen-nuclear magnetic resonance (1H-NMR). Results showed that microemulsions not only have good resistance to oral and gastric phases, but also lay a solid foundation for the release of bioactive compounds in the intestine. Fluorescence stability tests showed that microemulsions exhibit a remarkable fluorescence intensity in the digestive environment, indicating feasibility as a label-free delivery carrier. Moreover, in vitro release tests of bioactive compounds confirmed that an α-linolenic acid (ALA)-loaded microemulsion mainly released in the intestine, thereby achieving the aim of controlling the release of bioactive compounds. These results suggest that the synthesized fluorescent microemulsion, combining the favorable features of nontoxicity, antidigestive stability, remarkable fluorescence intensity, and controllable release, can be regarded as a promising label-free delivery carrier for oral administration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Ácido alfa-Linolénico / Emulsiones Idioma: En Revista: J Agric Food Chem Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Ácido alfa-Linolénico / Emulsiones Idioma: En Revista: J Agric Food Chem Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos